A new era of human and robotic lunar exploration is opening up exciting opportunities in scientific understanding as humanity reaches toward the Moon again. Missions such as the Artemis, Chang'e, Chandrayaan, and commercial programs offer incredible avenues to develop a deeper scientific understanding of our nearest celestial neighbor. This session highlights science that enables and is enabled by our return to the Moon. These include lunar science results from recent missions, preparations for upcoming lunar missions, as well as laboratory and computational investigations that will broaden our knowledge about the Moon and facilitate future lunar exploration. We welcome investigations of the Moon and beyond that will be uniquely enabled by being done from the Moon. Areas of particular interest include dust, volatiles, radiation, geological processes and their mutual interactions, as well as future lunar instruments and mission concepts.