The Parallel Fate and Transformation of Toxins in the Body and in the Atmosphere

Abstract:

Background. Pollutants emitted from combustion, namely polycyclic aromatic hydrocarbons, have been shown to include mutagenic and carcinogenic constituents, yet little is known whether aging of these pollutants in the atmosphere causes significant changes in toxicity. Current atmospheric measurements have shown the formation of active mutagens can occur in the atmosphere based on what is known in the field of toxicology. The parallel advancements in atmospheric measurements and toxicological assays merits the need for more cross talk between the atmospheric science and toxicology fields.

Objectives. Drawing from the literature in atmospheric sciences, toxicology, and public health, we aim to highlight the parallel fate and transformations of combustion pollutants that occur in the atmosphere and the body and their collective impact on public health.

Discussion. Research on the fate and transport of polycyclic aromatic hydrocarbons has been a major focus separately in toxicology and atmospheric chemistry. The advancements in atmospheric measurements has provided a more detailed look at the chemical composition of atmospheric pollutants and their transformation over time. Notably, the oxidation products of these polycyclic aromatics observed in the atmosphere have also been observed within the body. The knowledge gathered from both fields can help both toxicologist and atmospheric chemists identify key products that impact public health.

Conclusions. Integrating current toxicology knowledge of atmospherically aged pollution and atmospheric measurements into public health models will better predict the public health risks of combustion sources. Toxicology studies should evaluate the suite of atmospheric products to determine which products must be included in public health models.