Innovative designs, data sources, and analyses are essential to identify at-risk populations and track risk associated with various environmental hazards. Environmental risks – ranging from air pollution exposure, vector-borne diseases, harmful algal blooms, and urban heat islands – directly impact human health and surrounding aquatic, atmospheric, and terrestrial ecosystems. To address this global burden, multidisciplinary collaborations that integrate scientific approaches to mitigate risk and disease spread to local communities are key to enhance decision support applications. In this session, we aim to highlight the role of NASA Earth observations in applications that connect ecosystem risks to human health as well as sustainable solutions for enhanced global security. Possible topics include, but are not limited to, fieldwork applications, new emerging data products, environmental risk assessments in vulnerable communities, and citizen science campaigns, with the central goal of how NASA Earth observations enhance scientific communication and health decision-making.