Per- and polyfluoroalkyl substances (PFAS), principally perfluoroalkyl acids (PFAAs) and their precursors, are understood to be toxic and persistent organic chemicals that potentially pose a threat to soil and groundwater resources. PFAAs and associated precursors readily adsorb to soils and current remediation strategies for the media are limited, time consuming and expensive. Our prior work has demonstrated that ball milling is capable of reducing PFAS concentrations in amended silica sands and at least two different aqueous film-forming foam (AFFF) impacted soils. A study of six different perfluorooctanesulfonic acid (PFOS)- and perfluorooctanoic acid (PFOA)-amended sands of varying mineral composition were evaluated to determine the effect of media composition on mechanochemical destruction of PFAS. Successful destruction of PFOS and PFOA was observed in amended carbonates and iron-amended silica sand for the first time.