With the eminent return of humans to the Moon and in preparation for Mars, we are inspired to innovate novel solutions for the challenge of ensuring crew safety. These missions must take advantage of the possibilities for innovative Heliophysics science and space weather activities. As will be heard during this session, much of this work has begun. As Artemis progresses, humans will start to return to the Moon yearly. This opens up possibilities for the Moon to be the new Antarctica – where instruments can be deployed in larger arrays, serviced to maintain data collection, and replaced by the next generation instrumentation. Data collected on these missions will provide insights into Heliophysics processes enabling improved actionable information and space weather tool development. We invite submissions discussing how heliophysics will enable humanities safe return to the Moon, a look at current lunar-focused heliophysics and space weather studies, and future missions.