We invite submissions advancing our understanding of how climate change could affect agriculture and the food system across larger spatial scales. This session emphasizes extreme weather event impacts -- such as frequency and severity of droughts, heat waves, and excess moisture -- and on adaptation potentials and challenges. Other topics of interest include long-term crop production impacts, changes in interannual variability, cropland shifts, changes in irrigation water requirements and nutrient use efficiencies, CO₂ fertilization effects, trade and price responses, climate and crop model uncertainty assessments, crop nutritional quality, impact assessment of non-staple and less frequently studied crops, and many more. We particularly solicit studies leveraging latest climate change projections out of CMIP6, using various methodological approaches.