Owing to the highly interwoven nature of food-energy-water systems (FEWS), climate change and extreme weather will continue to challenge the capacity of these sectors to support human well-being and maintain critical environmental services. The resilience of FEWS to such climate and environmental stresses will serve as a major force shaping future decisions on the economy, national and international security for many decades to come. These issues are a quintessential interdisciplinary research challenge and will require a well-structured science agenda coupled with stakeholder engagement. The session calls for presentations from experts in climate dynamics, biogeochemistry, hydrology, water resource systems, agriculture, policy formulation, stakeholder engagement, and economics. The session will include stakeholder participation from a set of application domains including environmental management, regional land planning, farm crop and soil management, the energy production sector, and public utilities, all of which face increasingly complex strategic decisions in light of the growing climate challenge.