I will discuss recent advances in protein structure prediction and design. In the structure prediction area, I will discuss recent advances in high resolution protein structure prediction and the rosetta@home distributed computing project. In the protein design area, I will describe our current efforts towards (1) designing novel enzymes catalyzing reactions not catalyzed by naturally occurring enzymes, (2) designing new homing endonucleases which cleave specifically within genes of therapeutic importance for use in gene therapy, (3) designing novel high affinity protein-protein interfaces, and (4) designing vaccines for HIV.

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