Preliminary Program subject to change
BEC201 Evolutionary and Combinatorial Approaches to Metabolic Pathway and Strain Improvement
OverviewThis session aims at presenting pathway engineering approaches that combine the use of genomics information with evolutionary design methods to optimize production or broaden the structural diversity of product metabolites. Examples include the use of random point mutagenesis, gene recombination, transposon mutagenesis, and combinatorial gene deletion or gene addition analyses to modify existing metabolic pathways, create new pathways, and/or alter the function of specific genes within a pathway.
Primary SponsorMolecular Interactions and Intracellular Pathways (BEC2)

Chair

Claudia Schmidt-Dannert
Associate Professor, McKnight Presidential Fellow
Dept. Biochemistry, Molecular Biology & Biophysics
University of Minnesota
Minneapolis, MN 612-625-5782
Phone Number: (612) 625-5782
Email: schmi232@umn.edu

CoChair

Patrick C. Cirino
Assistant Professor
Penn State University
226A Fenske Lab
University Park, PA 16802-4400
Phone Number: 814-865-5790
Fax Number: 814-865-7846
Email: cirino@engr.psu.edu
Structural and Evolutionary Approaches for Engineering Polyketide Biosynthesis
Chaitan Khosla, Chemical Engineering, Stanford University, 381 North-South Mall, Stanford, CA 94305
Production of Artemisinic-11,12-Epoxide by Engineered Cytochrome P450 Bm3
Jeffrey A. Dietrich1, Yasuo Yoshikuni1, Karl Fisher2 and Jay Keasling1, (1)UCSF/UCB Joint Graduate Group in Bioengineering, 717 Potter Street, Bldg 977, MC 3224, Berkeley, CA 94720, (2)Amyris Biotechnologies, 5980 Horton St, Suite 450, Emeryville, CA 94608
Microbial Production of 3-Hydroxypropanoic Acid: a New Platform Chemical from Carbohydrates
Holly J. Jessen, Biotechnology Development Center, Cargill Incorporated, 2500 Shadywood Rd, Excelsior, MN 55331
Using Genomics to Direct Strain Selections
Ryan T. Gill, Department of Chemical and Biological Engineering, University of Colorado, ECCH 111 Campus Box 424, Boulder, CO 80309, Tanya Warnecke, University of Colorado, ECCH 111 Campus Box 424, Boulder, CO 80309, Michael D. Lynch, University of Colorado, ECCH 111, Campus Box 424, Boulder, CO 80309 and Amarjeet Singh, Chemical & Biological Engineering, University of Colorado at Boulder, 1111 Engineering Drive, Campus Box 424, Boulder, CO 80309

General Submissions