Preliminary Program subject to change
15C15 Systems Engineering of Biotechnological and Pharmaceutical Processes
OverviewThe session will focus on recent advances and future challenges in the use of dynamical analysis, control, and optimization methods in biological and pharmaceutical processes. We invite both fundamental and applied papers. However, theoretical contributions with experimental components are especially encouraged. Topics include but are not limited to: bioprocess optimization; bioreactor design; high cell density fermentation; cellular processes, ranging from genetic and metabolic networks, to signal transduction pathways, to cell populations; cell regulatory networks; mechanism-based modeling and analysis of biological processes including approaches that consider the details of the underlying biomolecular interactions; industrial bioprocesses; drug design.
Primary SponsorBioengineering (15c)
Co-Sponsor(s)Computing Systems and Technology Division (10), Systems and Process Control (10b), Engineering Fundamentals in Life Science (15d)

Chair

Radhakrishnan Mahadevan
Research Scientist
Genomatica, Inc.
5405 Morehouse Drive Suite 210
San Diego, CA 92121
Phone Number: 858-362-8562
Fax Number: 858-824-1772
Email: rmahadevan@genomatica.com

CoChair

Costas D. Maranas
Associate Professor
Penn State
112A Fenske Lab.
University Park, PA 16802
US
Phone Number: (814)863-9958
Fax Number: (814)865-7846
Email: costas@psu.edu
A Structured Model to Represent Sequential Substrate Uptake during Rifamycin B Fermentation in Complex Media
Pramod P. Wangikar1, Prashant Bapat2 and K V Venkatesh2, (1)Department of Chemical Engineering, Indian Institute of Technology Bombay, Dept of Chemical Eng, IIT Bombay Powai, Mumbai, 400076, India, (2)Chemical Engineering, Indian Institute of Technology Bombay, Dept of Chemical Eng, IIT Bombay Powai, Mumbai, 400076, India
Cybernetic Modeling Approach for Analysis and Redesign of Biochemical Pathways
Jamey D. Young and Doraiswami Ramkrishna, Purdue University, 480 Stadium Mall Drive, West Lafayette, IN 47907
Modelling and Bifurcation Studies of a Two-Stage Continuous Bioreactor for the Production of Poly-Beta-Hydroxybutyrate (PHB)
Mark A. Pinto and Charles D. Immanuel, Centre for Process Systems Engineering, Department of Chemical Engineering and Chemical Technology, Imperial College London, Exhibition Road, London SW7 2AZ, United Kingdom
Metabolic Engineering of Escherichia Coli through in Silico Design and Experimental Evolution
Stephen S. Fong1, Anthony Burgard2, Costas D. Maranas3 and Bernhard O. Palsson1, (1)Bioengineering, UCSD, 9500 Gilman Dr. Mailcode 0412, La Jolla, CA 92093-0412, (2)Genomatica, Inc., 5405 Morehouse Drive Suite 210, San Diego, CA 92121, (3)Department of Chemical Engineering, The Pennsylvania State University, University Park, PA 16802
Intermission
Dynamic Flux Balance Analysis of Yeast Primary Metabolism in Fed-Batch Culture
Jared Hjersted1, Michael A. Henson1 and Radhakrishnan Mahadevan2, (1)Department of Chemical Engineering, University of Massachusetts, 686 North Pleasant Street, Amherst, MA 01003-9303, (2)Genomatica, Inc., 5405 Morehouse Drive Suite 210, San Diego, CA 92121
Dynamics of Cell Populations Carrying Gene-Switching Networks with Fluorescent Protein Markers of Different Half-Lives
Stephanie Portle1, Thomas B. Causey2, Ka-Yiu San3, George N. Bennett2 and Nikos V. Mantzaris1, (1)Chemical and Biomolecular Engineering, Rice University, Houston, TX 77005, (2)Biochemistry and Cell Biology, Rice University, 6100 Main st, Houston, TX 77005, (3)Bioengineering, Rice University, 6100 Main st, Houston, TX 77005
Comprehending the Molecular Portraits of Hyper-Producers in Bioprocessing
Gargi Seth1, Robin J. Philp2, Mugdha Gadgil1, Miranda Yap2 and Wei-Shou Hu1, (1)Chemical Engineering and Materials Science, University of Minnesota, 421 Washington Ave SE, Minneapolis, MN 55455, (2)Bioprocessing Technology Institute, A-Star, Singapore

Food, Pharmaceutical & Bioengineering Division