Preliminary Program subject to change
15B02 Advances in Drug Delivery: Novel Delivery Mechanisms
OverviewThis session is devoted to fundamentals in the development of controlled and targeted drug delivery systems, investigation of new materials for drug delivery and ways to design intelligent controlled release systems. Of particular interest are studies combining characterization of physicochemical properties and their impact on drug delivery performance. Topics of interest include, but are not limited to: Novel drug release mechanisms and routes; Drug/polymer interactions, partitioning, solubilization; Kinetics, diffusion, dissolution; Controlled drug transport through tissue; Physical and biochemical methods of drug targeting; Delivery of proteins, genes, carbohydrates and vaccines; Supersaturated systems/pharmaceutical solids within drug formulations; Mathematical modeling; solids within drug delivery formulations. This session is the general drug delivery session, and complementary to sessions 15b03 and 15d10.
Primary SponsorPharmaceuticals (15b)
Co-Sponsor(s)Engineering Fundamentals in Life Science (15d)

Chair

Cory J. Berkland
Professor
University of Kansas
B53 Smissman
2095 Constant Avenue
Lawrence, KS 66047
US
Phone Number: 785-864-1455
Fax Number: 785-864-1454
Email: berkland@ku.edu

CoChair

Moriah Nof
Eli Lilly and Co.
Lilly Technology Center
Indianapolis, IN 46285
Phone Number: 317-655-1765
Fax Number: 317-651-9318
Email: mnof@lilly.com
Molecularly Designed Mucoadhesive pH Responsive Tethered Biomaterials
Joshua B. Thomas, Department of Chemical Engineering, University of Texas at Austin, 1 University Station, MC C0400, Austin, TX 78712, James W. McGinity, Division of Pharmaceutics, University of Texas at Austin, 1 University Station, Stop A1902, Austin, TX 78712 and Nicholas A. Peppas, Department of Chemical Engineering, CPE 3.466, 1 University Station, Code C0400, Austin, TX 78712
Development of a Long-Lasting Silicone Catheter Impregnated with Rifamipicin
Xuemei Liang1, Anfeng Wang1, Haiying Tang1, Ting Cao1, Steven O. Salley2, James P. McAllister II3 and K. Y. Simon Ng1, (1)Department of Chemical Engineering and Materials Science, Wayne State University, 5050 Anthony Wayne Dr., Detroit, MI 48202, (2)Wayne State University, 5050 Anthony Wayne Dr., Detroit, MI 48202, (3)Department of Neurological Surgery, Wayne State University, 4201 Antoine Street, UHC-6E, Detroit, MI 48201
Cytotoxic Activity, Transport, and Drug Release Mechanisms of Dendrimer- Methotrexate Conjugates on Sensitive and Resistant Cancer Cell Lines
Sezen Gurdag1, Rangaramanujam M. Kannan2, Sarah Staples3 and Larry Matherly3, (1)Wayne State University, 5050 Anthony Wayne Drive, Detroit, MI 48202, (2)Wayne State University, 1121 Engineering, 5050 Anthony Wayne Drive, Detroit, MI 48202, (3)Pharmacology, Wayne State University, 1121 Engineering, 5050 Anthony Wayne Drive, Detroit, MI 48202
Intermission
Ultrasonic Drug Release from Micelles Correlates with Subharmonic Emission
Ghaleb A. Husseini, Chemical Engineering Department, American University of Sharjah, Sharjah, United Arab Emirates, Mario A. Díaz de la Rosa, Department of Chemical Engineering, Brigham Young University, 350 CB, Provo, UT 84602, Eric S. Richardson, Mechanical Engineering Department, Brigham Young University, 350 CB, Provo, UT 84602, Douglas A. Christensen, Department of Bioengineering, University of Utah, Salt Lake City, UT 84112 and William G. Pitt, Department of Chemical Enginering, Brigham Young University, 350 CB, Provo, UT 84602
The Effects of Pharmaceuticals and Cell Media on the Micellar Structure and Gelation Behavior of Peo-Ppo-Peo Copolymers
Praveen K. Sharma, Pharmaceutical Research Institute, Bristol-Myers Squibb Co., 1 Squibb Drive, New Brunswick, NJ 08903 and Surita R. Bhatia, Chemical Engineering, University of Massachusetts, Amherst, 686 North Pleasant Street, Amherst, MA 01003-9303
Colloidal Polyelectrolyte Complexes for Drug Delivery: Implications of Molecular Characteristics on Targeting and Uptake by Vascular Endothelial Cells
Sean M. Hartig1, R. Robert Balcarcel1, Jeffrey M. Davidson2 and Ales Prokop1, (1)Department of Chemical Engineering, Vanderbilt University, 24th and Garland Aves., 107 Olin Hall, Nashville, TN 37235, (2)Department of Pathology, Vanderbilt University School of Medicine, VA Medical Center, 1310 21st Ave. South, Nashville, TN 37232
Modeling the Influence of Cyclodextrins on Oral Absorption of Saltform Drug in Immediate and Controlled Release Delivery
Ece D. Gamsiz1, Avinash G. Thombre2, Lee A. Miller2 and Rebecca L. Carrier1, (1)Chemical Engineering, Northeastern University, 342 Snell Engineering Center, Boston, MA 02115, (2)Pfizer, Inc., Eastern Point Road, Groton, CT 06340

Food, Pharmaceutical & Bioengineering Division