Preliminary Program subject to change
15B03 Advances in Drug Delivery: Biological Barrier Transport
OverviewThis session invites papers that focus on the design and development of novel methods for controlled drug delivery across the biological barriers, such as blood-brain, blood-retinal, intestinal and nasal barriers. These methods can incorporate, for example, nanocarriers, electrical field, magnetic field or ultrasound. Topics of interest include, but are not limited to: in vitro and in vivo studies of the effects of the delivery protocol on the integrity of the biological barriers, cellular uptake of nanocarrier/drug complexes, enhanced permeability mechanisms, and bioefficacy of penetrated drugs.
Primary SponsorPharmaceuticals (15b)
Co-Sponsor(s)Engineering Fundamentals in Life Science (15d)

Chair

Tao L. Lowe
Assistant Professor of Surgery, Bioengineering, and Material Sciences and Engineering
Pennsylvania State University
The Milton S. Hershey Medical Center
500 University Dr.
Hershey, PA 17033
U.S.A.
Phone Number: (717) 531-8602
Fax Number: (717) 531-4464
Email: tlowe@psu.edu

CoChair

Cory J. Berkland
Professor
University of Kansas
B53 Smissman
2095 Constant Avenue
Lawrence, KS 66047
US
Phone Number: 785-864-1455
Fax Number: 785-864-1454
Email: berkland@ku.edu
Design Principles of Chemical Permeation Enhancers for Transdermal Drug Delivery
Pankaj S. Karande1, Amit K. Jain1 and Samir Mitragotri2, (1)University of California Santa Barbara, 3229 Engineering II, Santa Barbara, CA 93106, (2)University of California, Santa Barbara, CA unknown
Fundamental Investigation of Transdermal Transport Models for Hydrophobic and Hydrophilic Drugs
Joseph Kushner IV, Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Bldg 66-253, Cambridge, MA 02139, Daniel Blankschtein, Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Bldg 66-444, Cambridge, MA 02139 and Robert Langer, Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Bldg E25-342, Cambridge, MA 02139
Transport of Amitriptyline across Capillary Walls in Isolated Rat Hearts
Marissa Fallon1, Jason A Flint2, Timothy E Morey2, Donn M Dennis2 and Anuj Chauhan1, (1)University of Florida, Chemical Engineering, Gainesville, FL 32611, (2)Anesthesiology, University of Florida, Chemical Engineering, Gainesville, FL 32611
A Facile and Reproducible in Vitro Blood-Brain Barrier Model
Eric Shusta1, Anthony R. Calabria2 and Christian Weidenfeller2, (1)University of Wisconsin, 1415 Engineering Drive, Madison, WI 53706, (2)Chemical and Biological Engineering, University of Wisconsin, 1415 Engineering Drive, Madison, WI 53715
Break
in Vivo Characterization of Microfluidic Probes for Convection Enhanced Drug Delivery
Keith B. Neeves1, William L. Olbricht1 and W. Mark Saltzman2, (1)School of Chemical and Biomolecular Engineering, Cornell University, 120 Olin Hall, Ithaca, NY 14853, (2)Biomedical Engineering, Yale University, 15 Prospect Street, New Haven, CT 06520
Novel Nanoparticles for Controlled Drug Delivery across the Blood-Brain Barrier
Sailendra N. Nichenametla, Integrative Biosciences, Pennsylvania State University, 500 University Drive, Hershey, PA 17033, Annie Mitsak, Biomedical Engineering, University of Virginia, Charlottesville, VA 22904, James Bauer, Surgery, Pennsylvania State University, 500 University Drive, Hershey, PA 17033, Young Shin Kim, Bioengineering, Pennsylvania State University, 500 University Drive, Hershey, PA 17033 and Tao L. Lowe, Surgery, Bioengineering, and Material Sciences & Engineering, Pennsylvania State University, 500 University Drive, Hershey, PA 17033
Experimental and Theoretical Modeling of Intracellular Drug Delivery Following Acoustic Cavitation
Vladimir G. Zarnitsyn, Robyn K. Schlicher, Christina Allen and Mark R. Prausnitz, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA 30332-0100

Food, Pharmaceutical & Bioengineering Division