Preliminary Program subject to change
15B05 Application of ChE Fundamentals to Active Pharmaceutical Ingredient (API) Process Development
OverviewThis session focuses on the application of chemical engineering principles to extract kinetic, thermodynamic and transport parameters from data-rich experiments at the lab and pilot plant scale. Of particular interest are talks related to the development of robust, cost-effective and scaleable processes for API and intermediate production.
Primary SponsorPharmaceuticals (15b)

Chair

Shailendra V. Bordawekar
Research Investigator
Abbott Laboratories
1401 Sheridan Rd
Bldg. R8-3, Dept. R452
North Chicago, IL 60064
Phone Number: 847 935 0212
Email: shailendra.bordawekar@abbott.com

CoChair

Shekhar K. Viswanath
Process Engineering Group Leader
Abbott Labs
1401 Sheridan Road
R13-3
North Chicago, IL 60064
Phone Number: 8479358660
Fax Number: 8479385932
Email: shekhar.viswanath@abbott.com
Solvent and Catalyst Recovery in the Pharmaceutical Manufacturing Industry
Jason Davis, Joseph T. Sullivan and Nick Anousis, Technical Operations, Merck and Co., Inc., 2778 South East Side Highway, Elkton, VA 22827
Batch Grinding Kinetics and Particle Shape of Active Pharmaceutical Ingredients by Fluidized-Bed Jet-Milling
Tadashi Fukunaka1, Boris Golman2 and Kunio Shinohara2, (1)Banyu Pharmaceutical CO., LTD., 9-1, Kamimutsuna 3-chome, Okazaki, Japan, (2)Division of Chemical Process Engineering, Graduate School of Engineering, Hokkaido University, Nishi 8, Kita 13, Kita-ku, Sapporo, Japan
Drying of a Monohydrate Api under Thermodynamically Safe Conditions
G. Scott Jones1, Raymond Scaringe2 and Shawn Yin2, (1)Process R&D, Bristol-Myers Squibb, One Squibb Drive, New Brunswick, NJ 08903, (2)Bristol-Myers Squibb, One Squibb Drive, New Brunswick, NJ 08903
Estimating Solubility of Organic Salts with Enrtl-Sac Model
Chau-Chyun Chen and Yuhua Song, Aspen Technology, Inc., 10 Canal Park, Cambridge, MA 02141
Intermission
Trouble-Shooting of High Residual Solvent during Drying of Biological Derived Api
Yubo Yang, Stephen Tyler and Kenneth Wilson, Dept. 04AR, R13-2, Abbott Laboratories, 1401 Sheridan Road, North Chicago, IL 60064-6292
Studying Hydraulic Deterioration of Large Scale Chromatography Columns
Harish Santhanam, Bio Manufacturing, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285 and Yi Xie, Engineering Tech Center, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285
Development of Efficient and Robust Nitro Reduction Process: Catalyst Selection and Thermo-Kinetic Understanding
Jale Muslehiddinoglu, Srinivas Tummala, Nicolas Cuniere, William Merkl, Richard Schild and Lucius Rossano, Process Research and Development, Bristol-Myers Squibb Company, One Squibb Drive, New Brunswick, NJ 08903

Food, Pharmaceutical & Bioengineering Division