Preliminary Program subject to change
15D02 Advances in Drug Delivery: Targeted Delivery
OverviewWe invite papers from the broad area of drug and gene delivery, with a focus on targeted or enhanced delivery, rather than controlled release . Recent advances in preparation, in vitro and in vivo characterization of targeted delivery systems, especially with afocus on specific disease models are welcome. Some of the areas of interest include: (1) the use of targeted non-viral and viral vectors for gene delivery; (2) the preparation of targeted conjugates for drug and/or imaging agent delivery; (3) Use of external fields/stimuli to improve targeting; (4) Use of stimuli-sensitive polymers; (5) Approaches for investigating the targeting efficiency in vitro and in vivo. Authors are encouraged to contact the sessions chairs in case of specific questions.
Primary SponsorEngineering Fundamentals in Life Science (15d)
Co-Sponsor(s)Pharmaceuticals (15b)

Chair

Rangaramanujam M. Kannan
Associate Professor, Chemical Engineering and Materials Science
Wayne State University
1121 Engineering
5050 Anthony Wayne Drive
Detroit, MI 48202
Phone Number: 313-577-3879
Fax Number: 313-577-3810
Email: rkannan@che.eng.wayne.edu

CoChair

Suzie Pun
Assistant Professor
University of Washington
Box 352255
Seattle, WA 98195
Phone Number: 206 685 3488
Fax Number: 206 543 6124
Email: spun@u.washington.edu
The Modular Antibody Targeting of Catalase Loaded Nanocarriers Provides Protection of Endothelial Cells from H2o2 Mediated Injury
Tom Dziubla1, Vladimir Shuvaev1, Silvia Muro1 and Vladimir Muzykantov2, (1)Institute for Environmental Medicine, University of Pennsylvania School of Medicine, 1 J Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104, (2)Institute for Environmental Medicine, Department of Pharmacology, University of Pennsylvania School of Medicine, 1 J Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104
Liver Targeting of Gold Nanoparticles: Effects of Size and Surface Modification on Preferential Hepatocyte Uptake
Jamie M. Bergen, Horst von Recum, Thomas T. Goodman, Archna P. Massey and Suzie H. Pun, Bioengineering, University of Washington, Box 352255, Seattle, WA 98195
Controlling the Production of Exhaled Bioaerosols
Jennifer Fiegel1, Wiwik Wanatabe2, Gerald G. Fuller3 and David Edwards1, (1)Division of Engineering and Applied Sciences, Harvard University, 40 Oxford St., Cambridge, MA 02138, (2)Pulmatrix Inc., Cambridge, MA 02139, (3)Stanford University, Dept. of Chemical Engineering, Stanford, CA 94305-5025
Formulation of the Anti-Inflammatory Cationic Lipid Dexamethasone-Spermine with Adenovirus for Targeted Gene Delivery to the Lung Airway Epithelia
Amber R. Price, University of Pennsylvania, 3340 Smith Walk, Room 1150 Vagelos, Philadelphia, PA 19104, Jeff Gruneich, University of Pennsylvania, 3440 Smith Walk, Room 1150 Vagelos, Philadelphia, PA 19104, Maria Limberis, University of Pennsylvania School of Medicine, 125 South 31st Street, Philadelphia, PA 19104, James M. Wilson, University of Pennsylvania School of Medicine, The Wistar Institute, 125 South 31st Street, Philadelphia, PA 19104 and Scott L. Diamond, University of Pennsylvania, 1024 Vagelos Research Labs, 3340 Smith Walk, Philadelphia, PA 19104
Intermission
Targeted Delivery of Thrombolytic Agents Using Complexation and Conjugation with Dendritic Polymers
Rajyalakshmi Inapagolla, Wayne State University (Department of Chemical Engineering), 5050 Anthony Wayne Drive, Detroit, MI 48202, Xiangtao Wang, Pediatrics, Wayne State University (Department of Chemical Engineering), 5050 Anthony Wayne Drive, Detroit, MI 48202, Sujatha Kannan, Pediatrics, Children's Hospital of Michigan, Wayne State University (Department of Chemical Engineering), 5050 Anthony Wayne Drive, Detroit, MI 48202 and Rangaramanujam M. Kannan, Wayne State University, 1121 Engineering, 5050 Anthony Wayne Drive, Detroit, MI 48202
Poly(Lactide-Co-Glycolide) Nanoparticles for Targeted and Controlled Delivery of Doxorubicin for the Treatment of Cancer
Tania Betancourt, Biomedical Engineering, The University of Texas at Austin, 1 University Station, Mail Code C0800, Austin, TX 78712, Brandon Brown, Department of Biology, The University of Texas at Austin, 1 University Station, Austin, TX 78712 and Lisa Brannon-Peppas, Department of Biomedical Engineering, The University of Texas at Austin, 1 University Station, Mail Code C0300, Austin, TX 78712
Targeted Drug Delivery into the Human Brain
MahadevaBharath R. Somayaji1, Libin Zhang1, Michalis Xenos1, Srinivasa Kondapalli1, Sinan Tumturk1, Richard Penn2 and Andreas A. Linninger1, (1)Chemical Engineering & Bioengineering, University of Illinois at Chicago, 810 S. Clinton St., Chicago, IL 60607, (2)Neurosurgery, University of Chicago, Center for Advanced Medicine, 5758 S. Maryland Avenue, Chicago, IL 60637

Food, Pharmaceutical & Bioengineering Division