Preliminary Program subject to change
15D04 Biomedical Applications of Systems Biology
OverviewSystems biology, which stands at the nexus of biological and computational sciences and engineering, offers the promise of systematically studying biological systems, not only in a descriptive manner but also with predictive ability. The comprehensive classification and comparison of biomolecular sequences, structures and functions can guide the development of statistical methods and computational predictive tools and experimental approaches that will provide new insights and opportunities to improve human condition. Experimental methods that enable systematic exploration of living organisms are resulting to the rapid transformation of biology to a data-driven science. This necessitates the development of mathematical/computational modeling and data mining algorithms and that will enable scientists and engineers to seamlessly harness biological information and extract knowledge to guide the development of therapeutic and biotechnology solutions. We are inviting presentations on both experimental and theoretical aspects of systems biology research. Of specific interest are presentations that combine both approaches to generate a comprehensive picture of biological problems.
Primary SponsorEngineering Fundamentals in Life Science (15d)
Co-Sponsor(s)Topical 4 - Systems Biology (T4)

Chair

Arul Jayaraman
Assistant Professor
Texas A&M University
Department of Chemical Engineering
3122 TAMU
College Station, TX 77840
Phone Number: 617-371-4874; 979-845-3361
Fax Number: 979-845-6446
Email: arul.jayaraman@chemail.tamu.edu

CoChair

Yiannis Kaznessis
University of Minnesota
Chemical Engineering and Materials Science Department
151 Amundson Hall
Minneapolis, MN 55455-0132
Phone Number: 612-625-1313
Email: yiannis@cems.umn.edu
Genome-Scale Analysis of Translation in S. Cerevisiae: Insights into System Response and Regulation
Vassily Hatzimanikatis, Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Road, Room E136, Evanston, IL 60208-3120 and Amit Mehra, Northwestern University, 2145 Sheridan Rd E136, Evanston, IL 60208
Computational Analysis of Combinatorial Gene Regulation in the Liver
Joseph L. Vitolo, Rutgers University, Dept. of Chemical Engineering, Piscataway, NJ 08854, Ioannis (Yannis) P. Androulakis, Rutgers - The State University of New Jersey, Biomedical Engineering Department, Chemical & Biochemical Engineering Department, Room 108 BME Building - 617 Browser Road, Piscataway, NJ 08854 and Charles M. Roth, Rutgers University, 98 Brett Road, Piscataway, NJ 08854
Graph Theory-Flux Analysis Framework for Tissue-Specific Modeling of Metabolic Network Structure and Function
Ryan P. Nolan1, Yaguang Si1 and Kyongbum Lee2, (1)Tufts University, 4 Colby Street, Medford, MA 02155, (2)Tufts University, 4 Colby Street, Room 142, Medford, MA 02155, U.S.A.
Knowledge-Based Integration of Metabolic and Genetic Information to Identify Targets of Fatty Acid Toxicity
Shireesh Srivastava, Michigan State University, 2527 Engineering Building, East Lansing, MI 48824 and Christina Chan, Chemical Engineering and Materials Science, Michigan State University, 2527 Engineering Building, East Lansing, MI 48824
Intermission
Advances in Metabolic Flux Analysis from Stable Isotope Experiments: Theory and Applications
Maciek R. Antoniewicz, MIT, 77 Massachusetts Avenue, room 56-439, Cambridge, MA 02139, Joanne K. Kelleher, MIT, 77 Mass Ave, Room 66-401, Cambridge, MA 02139 and Gregory Stephanopoulos, Chemical Engineering, MIT, 66-264 MIT 77 Massachusetts Ave, Cambridge, MA 02139
Megakaryocyte Development Illuminated by Transcriptional Analysis
Peter G. Fuhrken, Chi Chen, William M. Miller and Eleftherios T. Papoutsakis, Chemical and Biological Engineering, Northwestern University, 2145 N. Sheridan Rd., Tech E136, Evanston, IL 60208
Identification of Important Signaling Proteins and Stimulants for the Production of Cytokines in Raw 264.7 Macrophages
Sylvain Pradervand, Bioinformatics and Data Coordination Laboratory, Alliance for Cellular Signaling, San Diego Supercomputer Center, University of California San Diego, 9500 Gilman Dr MC 0505, La Jolla, CA 92093, Mano R. Maurya, Laboratory for Bioinformatics and Computational Biology, San Diego Supercomputer Center, University of California San Diego, 9500 Gilman Drive, MC 0505, La Jolla, CA 92093-0505 and Shankar Subramaniam, San Diego Supercomputer Center, Department of Bioengineering, Department of Chemistry & Biochemistry, University of California San Diego, 9500 Giman Drive, La Jolla, CA 92093-0505

Food, Pharmaceutical & Bioengineering Division