Preliminary Program subject to change
15D05 Engineering Approaches in Gene Delivery
OverviewThis session will focus on application of engineering principles towards the fulfillment of gene therapy as a therapeutic modality. Talks related to both viral and non-viral delivery approaches are encouraged. Presentations devoted to the development of improved methods of gene transfer and to the analysis of extracellular and intracellular transport and reaction processes are of interest, as are those related to the standardization of gene transfer assays and the processing of gene transfer vectors. Specific topics of interest include, but are not limited to: design and synthesis of novel formulations and systems for improved gene delivery; experimental measurement and quantitative modeling/analysis of vector-cell interactions and intracellular trafficking; effects of processing and storage conditions on gene transfer vectors; novel assays for monitoring of gene transfer steps or clinical efficacy.
Primary SponsorEngineering Fundamentals in Life Science (15d)

Chair

Daniel W. Pack
Assistant Professor
University of Illinois
MC-712, Box C-3
600 S. Mathews Ave.
Urbana, IL 61801
United States
Phone Number: 217-356-0806
Fax Number: 217-333-5052
Email: dpack@uiuc.edu

CoChair

Lonnie D Shea
Assistant Professor
Northwestern University
2145 Sheridan Rd / E156
Evanston, IL 60208-3120
Phone Number: 847-491-7043
Fax Number: 847-491-3728
Email: l-shea@northwestern.edu
Self-Assembling Linear-Dendritic Hybrid Polymers for Receptor-Mediated Gene Delivery
Kris C. Wood, Robert Langer and Paula T. Hammond, Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room 66-525, Cambridge, MA 02139
Quantitative Evaluation of the Role of Vector in the Dynamics of Antisense Effects
Sumati Sundaram, Li Kim Lee and Charles Roth, Chemical and Biochemical Engineering, Rutgers University, 98 Brett Road, Piscataway, NJ 08854
Short and Long Time Dynamics of Synthetic Gene Vectors in Mammalian Cells
Chinmay H. Pangarkar1, Tuan A. Dinh1 and Samir Mitragotri2, (1)University of California, Santa Barbara, Dept. of Chemical Engineering, Santa Barbara, CA 93106, (2)University of California, Santa Barbara, CA unknown
Engineering Substrate-Mediated Gene Delivery with Self-Assembled Monolayers
Angela K. Pannier, Interdepartmental Biological Sciences, Northwestern University, 2145 Sheridan Rd, TECH E136, Evanston, IL 60208 and Lonnie D. Shea, Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Road, Tech E136, Evanston, IL 60208
Intermission
Engineering Bacterial Outer Membrane Vesicles for DNA Vaccine Delivery
David Chen1, Jae-Young Kim1, Anne M. Doody2, Matthew DeLisa1 and David Putnam2, (1)School of Chemical and Biomolecular Engineering, Cornell University, 120 Olin Hall, Ithaca, NY 14853, (2)Department of Biomedical Engineering, Cornell University, 120 Olin Hall, Ithaca, NY 14853
A Viral/Non-Viral Hybrid Gene Delivery Vector
Josh Ramsey and Daniel W. Pack, Chemical and Biomolecular Engineering, University of Illinois, Box C-3, 600 S. Mathews Ave., Urbana, IL 61801
Directed Evolution of Aav to Generate Mutants with Enhanced Transport Properties
James T. Koerber1, Narendra Maheshri1 and David V. Schaffer2, (1)UC Berkeley, 201 Gilman Hall, Berkeley, CA 94720, (2)University of California at Berkeley, Department of Chemical Engineering, 201 Gilman Hall, Berkeley, CA 94720-1462

Food, Pharmaceutical & Bioengineering Division