Preliminary Program subject to change
15D06 Intracellular Processes
OverviewThe focus of this session is the quantitative analysis of intracellular processes at the molecular level, including but not limited to studies of signal transduction, cytoskeletal dynamics, protein trafficking, gene expression, and metabolic and transcriptional networks. Experimental studies and data-driven or theoretical models of intracellular processes, including the analysis of cell biochemical and subcellular imaging data, will be highlighted. The session will consist of 15-20 minute talks by 7-10 speakers selected from abstracts submitted to the session.
Primary SponsorEngineering Fundamentals in Life Science (15d)

Chair

Chetan J. Gadgil
Scientific Computing and Mathematical Modeling
GlaxoSmithKline
5.3751A , P.O. Box 13398
Research Triangle Park, NC 27709
Phone Number: 919-483-5024
Fax Number: 919-315-2137
Email: gadgil@msi.umn.edu

CoChair

Jason M. Haugh
Assistant Professor
Chemical & Biomolecular Engineering
North Carolina State University
Box 7905, Engineering Bldg. I
911 Partners Way
Raleigh, NC 27695-7905
Phone Number: (919) 513-3851
Fax Number: (919) 515-3465
Email: jason_haugh@ncsu.edu
Altered Egfr Trafficking and Signaling in Iressa-Sensitive Human Cell Lines
Matthew J. Lazzara, Biological Engineering, MIT, 77 Massachusetts Avenue, 56-389, Cambridge, MA 02139, Paul Jasper, Biology, MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, Peter Sorger, Biology, MIT, 77 Massachusetts Avenue, Camrbidge, MA 02114 and Douglas A. Lauffenburger, Biological Engineering, MIT, 77 Massachusetts Avenue, 56-341, Cambridge, MA 02139
Experimentation, Modeling and Parameter Sensitivity Analysis Suggest a Role of Erk in Receptor down-Modulation during T Cell Signaling
Yanan Zheng1, Marietta Harrison2 and Ann Rundell1, (1)Biomedical Engineering, Purdue University, West Lafayette, IN 47907, (2)Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907
Cell Fate Determination by Multiple Signaling Pathways: Genome-Wide Analysis and Modeling of Pattern Formation in Drosophila Egg Development
Nir Yakoby1, Chris A. Bristow1, Rachel Kalifa1, Gertrud Schupbach2 and Stas Shvartsman1, (1)Department of Chemical Engineering and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, (2)Princeton University, Department of Molecular Biology, Princeton, NJ 08544
Apoptotic Signaling Pathways in Megakaryocytes
Lisa M. Giammona, Eleftherios T. Papoutsakis and William M. Miller, Northwestern University, 2145 N. Sheridan Rd., Tech E136, Evanston, IL 60208
Intermission
Topology and Dynamics of Pro-Mitogenic Β-Catenin Signaling in Mammary Epithelial Cells
Nicholas A. Graham, California Institute of Technology, 1200 E. California Blvd, MC 210-41, Pasadena, CA 91125 and Anand R. Asthagiri, California Institute of Technology, Division of Chemistry and Chemical Engineering, Mail Code 210-41, Pasadena, CA 91125
Determination and Analysis of the Dynamic Mechanisms That Precede Long-Term Depression in Cerebellar Purkinje Cells
Nicholas Hernjak, Boris M. Slepchenko and Leslie M. Loew, Center for Cell Analysis and Modeling, University of Connecticut Health Center, 263 Farmington Ave. MC1507, Farmington, CT 06030
Modeling of Heterotrimeric G-Protein Mediated Calcium Response in Raw 264.7 Macrophage Cells
Mano R. Maurya, San Diego Supercomputer Center, University of California San Diego, 9500 Gilman Drive, MC 0505, La Jolla, CA 92093-0505 and Shankar Subramaniam, San Diego Supercomputer Center, Department of Bioengineering, Department of Chemistry & Biochemistry, University of California San Diego, 9500 Giman Drive, La Jolla, CA 92093-0505

Food, Pharmaceutical & Bioengineering Division