Preliminary Program subject to change
15C13 Cell Culture Process Development and Monitoring
OverviewThis session will focus on recent developments in the field of cell culture with emphasis on application in therapeutic protein productivity enhancement. Methods for improving the performance of cell culture processes, including media development, process parameter adjustments, and scale up/scale down methods, as well as the effect of these methods on product quality, will be emphasized. Additionally, innovations in cell culture technology, including sensors and analyzer technology, as well as bioreactor and control systems may be showcased. Potential audience of the session include students as well as scientists and engineers from academia and biotech industry involved in cell culture process R&D.
Primary SponsorBioengineering (15c)
Co-Sponsor(s)Systems and Process Control (10b)

Chair

John H. Chon
Process Engineering Manager
Genzyme Corporation
BioEngineering
45 New York Avenue
Framingham, MA 01701
Phone Number: (508) 271-3684
Fax Number: (508) 271-3454
Email: John.Chon@genzyme.com

CoChair

Jean-Francois Hamel
Massachusetts Institute of Technology
Department of Chemical Engr.
56-483
Cambridge, MA 02139-4307
Phone Number: 617 258-6665
Fax Number: 617 258-9344
Email: jhamel@mit.edu
Assessing Robustness for Cell Line Selection
Andrew M. Rusiniak, Gregory M. Mueller, Steven T. Rose, Guillermo Miroquesada and Xuejun (Sherry) Gu, Bioprocess Research & Development, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285
Analysis of Mab Production-Enhancing Compounds
Tiffany D. Rau and R. Robert Balcarcel, Chemical Engineering Department, Vanderbilt University, VU Station B #351604, 2301 Vanderbilt Place, Nashville, TN 37235-1604
A Simple Strategy to Custom-Optimize Feed Streams for Fed-Batch Processes
Pik Leng Wong1, Sherri Spear2, Jane McIninch3, Claudia W. Buser1 and John H. Chon1, (1)BioEngineering, Genzyme Corporation, Framingham, MA 01701, (2)ALTA, Genzyme Corporation, Framingham, MA 01701, (3)TPE, Genzyme Corporation, Framingham, MA 01701
Computational Approach to Characterization of Cell-Culture Bioreactors
Kumar Dhanasekharan1, John Strauss1, Atul Gupta2, Kenneth Hamilton2, Sanjeev Ahuja2, Basav Ghosh2, David Keller2 and Alex Fotopoulos2, (1)Fluent Inc., 10 Cavendish Ct., Lebanon, NH 03766, (2)Biogen-IDEC
Intermission
Method to Identify Significant Shifts in Nonlinear Systems
Steven T. Rose, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285
Online Performance Monitoring of Recombinant Protein Production in a Fed-Batch Reactor
Mahalingam Velu, Department of Biotechnology, Indian Institute of Technology,Madras, Chennai, India and Guhan Jayaraman, Indian Institute of Technology,Madras, Chennai, India
Cell Culture and Fermentation Control and Data Management
Meg Kay, WireWorks West, 965 Mission Street Suite 600, San Francisco, CA 94103

Food, Pharmaceutical & Bioengineering Division