Preliminary Program subject to change
15C17 Advances in Systems Biology: Experimental Methods and Applications
OverviewDevelopments in high throughput technologies have allowed for rapid improvement of many biological species and systems including enzymes, protein complexes, cellular pathways and whole organisms. The current challenge is how to apply these technologies for enabling discoveries in many diverse areas of biochemical technology such as metabolic engineering, drug discovery, tissue engineering, and bioprocess development. This session will include contributions that describe applications of existing technologies (e.g. directed evolution, genomic and proteomic information in cellular and metabolic engineering), improvement and development of new technologies and methodologies (e.g. new combinatorial display techniques, improvements in proteome and transcriptome technologies), and computational and mathematical frameworks for the quantitative analysis of the available information (e.g. computational approaches to library construction and prescreening, systems engineering application on biological systems, computational methods for prediction of protein structure and function).
Primary SponsorBioengineering (15c)

Chair

Matthew P. DeLisa
Assistant Professor
Cornell University
School of Chemical and Biomolecular Engineering
254 Olin Hall
Ithaca, NY 14853
Phone Number: 607-254-8560
Fax Number: 607-255-9166
Email: md255@cornell.edu

CoChair

Charles M. Roth
Assistant Professor
Rutgers University
98 Brett Road
Piscataway, NJ 08854
Phone Number: 732-445-4109
Fax Number: 732-445-2581
Email: cmroth@rci.rutgers.edu
Genomics Tools for Elucidating the Function of Trait Conferring Genes
Michael D. Lynch1, Tanya Warnecke1, Amarjeet Singh2 and Ryan T. Gill3, (1)University of Colorado, ECCH 111 Campus Box 424, Boulder, CO 80309, (2)Department of Chemical and Biological Engineering, University of Colorado, Campus Box 424, Boulder, CO 80309, (3)Chemical and Biological Engineering, University of Colorado, 1111 Engineering Dr., CB 424/ ECCH 111, Boulder, CO 80309
Proteomics-Based Systems Biology Study of the Phosphorus Starvation Response in the Cyanobacterium Synechocystis Sp. Strain Pcc6803
Chee Sian Gan1, Nigel G. Ternan2, Geoffrey McMullan2, Kenneth F. Reardon3 and Phillip C. Wright4, (1)Chemical and Process Engineering, University of Sheffield, Mappin Street, Sheffield, S1 3JD, United Kingdom, (2)School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, United Kingdom, (3)Colorado State University, Department of Chemical Engineering, Fort Collins, CO 80523-1370, (4)Department of Chemical and Process Engineering, The University of Sheffield, Biological & Environmental Systems Group, Mappin Street, Sheffield, S1 3JD, United Kingdom
Enabling Cell Factory Design through High-Throughput and Quantitative Metabolome Analysis
Michael C. Jewett and Jens Nielsen, Center for Microbial Biotechnology, Technical University of Denmark, BioCentrum-DTU, Kgs. Lyngby, 2800, Denmark
Study of Heat Shock Effects on Inflammatory Signaling Using a Microfluidic Living Cell Array
Sihong Wang, Kevin R. King, Kenneth J. Wieder, Mehmet Toner, Arul Jayaraman and Martin L. Yarmush, Massachusetts General Hospital/Shriners Burn Hospital/Harvard Medical School, 51 Blossom Street, Boston, MA 02114
Intermission
A High-Throughput Screen for Poly-3-Hydroxybutyrate for Inverse Metabolic Engineering of Recombinant Escherichia Coli and Synechocystis Pcc 6803
Keith E. Tyo, Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139, Hang Zhou, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139, Hal S. Alper, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room 56-422, Cambridge, MA 02139 and Gregory Stephanopoulos, Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room 56-422, Cambridge, MA 02139
Systematic Analysis of Erbb Induced Signaling, Proliferation, and Migration
Neil Kumar1, Alejandro Wolf-Yadlin2, Forest White2 and Douglas Lauffenburger1, (1)Chemical Engineering, Massachusetts Institute of Technology, Room 56-379 77 Massachusetts Ave., Cambridge, MA 02139, (2)Bioengineering, Massachusetts Institute of Technology, Room 56-379 77 Massachusetts Ave., Cambridge, MA 02139
High Throughput Approach to Drug Discovery: Sars Coronavirus - a Case Study
Dhaval N. Gosalia, University of Pennsylvania, 1150 Vagelos Labs,3340 Smith Walk, Philadelphia, PA 19104, Graham Simmons, Department of Microbiology, Philadelphia, PA 19104, Scott L. Diamond, University of Pennsylvania, 1024 Vagelos Research Labs, 3340 Smith Walk, Philadelphia, PA 19104 and Paul Bates, Department of Microbiology, University of Pennsylvania, Philadephia, PA 19104

Food, Pharmaceutical & Bioengineering Division