Preliminary Program subject to change
15D09 Gene Delivery
OverviewThe field of gene therapy and vaccine design has made significant strides in the past several years, but significant challenges remain, particularly in the design and optimization of gene delivery vehicles. This session will focus on issues related to vector design, both viral and synthetic. These issues will include investigations of the mechanism of gene delivery by various vectors, including analysis of interactions between vectors, tissues, and cells in the steps involved in the gene delivery pathway. In addition, emphasis will be placed on the design and enhancement of vectors to improve their capabilities, including efficiency and targeting, and we encourage analysis of the structure-function relationship of delivery vehicles. Finally, this session will also discuss methods to improve the production of both viral and nonviral vehicles.
Primary SponsorEngineering Fundamentals in Life Science (15d)

Chair

Stelios T. Andreadis
Associate Professor
SUNY at Buffalo
908 Furnas Hall
Amherst, NY 14260
Phone Number: 716-645-2911 ext. 2204
Fax Number: 716-645-3822
Email: sandread@eng.buffalo.edu

CoChair

David V. Schaffer
Assistant Professor
University of California at Berkeley
Department of Chemical Engineering
201 Gilman Hall
Berkeley, CA 94720-1462
Phone Number: 510-643-5963
Fax Number: 510-642-4778
Email: schaffer@cchem.berkeley.edu
Egf Receptor Signaling Affects Retroviral Gene Transfer to Primary Epidermal Cells
Raghvendra Singh, SUNY at Buffalo, 303 Furnas Hall, Dept. of Chemical Engg, University at Buffalo (North Campus), Amherst, NY 14260 and Stelios T. Andreadis, SUNY at Buffalo, 908 Furnas Hall, Amherst, NY 14260
Engineering Enhanced Retroviral Vectors for Gene Therapy through the Generation and Selection of 6xhis Peptide Insertion Libraries into Vsv-G
Julie H. Yu, Department of Chemical Engineering, University of California, Berkeley, 201 Gilman Hall, Berkeley, CA 94720-1462 and David V. Schaffer, University of California at Berkeley, Department of Chemical Engineering, 201 Gilman Hall, Berkeley, CA 94720-1462
Baculovirus Transduction of Human Mesenchymal Progenitor Cells Is Dependent on Differentiation Lineages
Yi-Chen Ho1, Kuei-Chun Wang1, Shiaw-Min Hwang2 and Yu-Chen Hu1, (1)Department of Chemical Engineering, National Tsing Hua University, 101, Sec. 2, Kuang Fu Rd., Hsinchu, Taiwan, (2)Bioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu, Taiwan
Intermission
Enhanced Stability of Retrovirus by Directed Evolution
Halong Vu, Chemical and Biomolecular Engineering, University of Illinois, Box C-3, 600 S. Mathews Ave., Urbana, IL 61801 and Daniel W. Pack, Chemical and Biomolecular Engineering, University of Illinois, Box C-3, 600 S. Mathews Ave, Urbana, IL 61801
Population Dynamics of Defective Interfering Virus-like Particles
Kristen Stauffer and John Yin, Chemical Engineering, University of Wisconsin - Madison, 1415 Engineering Drive, Madison, WI 53706
Enhancement of Retroviral Transduction Using Electrical Fields
Yu-Hsiang Lee, University of Southern California, Department of Chemical Engineering and Materials Science, 925 Bloom Walk, PCE 300, Los Angeles, CA 90089-1211 and Ching-An Peng, University of Southern California, Department of Chemical Engineering and Materials Science, 925 Bloom Walk, HED 208, Los Angeles, CA 90089-1211

Food, Pharmaceutical & Bioengineering Division