Preliminary Program subject to change
15D17 Engineering Improvements in Cancer Diagnosis and Therapy: Novel Therapeutic Approaches
OverviewTremendous advances in biology, including but not limited to high-profile areas such as genomics and stem cells, have provided new hope for improvements in the diagnosis and treatment of cancer. Engineers have much to offer in this endeavor, in areas such as mathematical modeling (at levels ranging from whole body pharmacokinetic down to cellular and molecular dynamics), transport in tumors, development of novel drug delivery strategies and data mining. This session will highlight chemical and bio-engineering methodologies for bringing these hopes closer to practice. Studies involving modeling, experiments or both are welcome. This session will particularly highlight novel therapeutic approaches, such as: personalized medicine based on genetics and gene expression profiles, angiogenesis and anti-angiogenic therapies, targeted drug delivery approaches, gene and oligonucleotide therapies.
Primary SponsorEngineering Fundamentals in Life Science (15d)

Chair

Charles M. Roth
Assistant Professor
Rutgers University
98 Brett Road
Piscataway, NJ 08854
Phone Number: 732-445-4109
Fax Number: 732-445-2581
Email: cmroth@rci.rutgers.edu

CoChair

Neil S Forbes
Assistant Professor
University of Massachusetts
159 Goessmann Hall
Department of Chemical Engineering
Amherst, MA 01003
US
Phone Number: (413) 577 - 0132
Fax Number: (413) 545 - 1647
Email: forbes@ecs.umass.edu
Isolation of Tumor Targeting Peptides Using Fluorescent Bacterial Display Libraries
Karen Y. Dane, Jeffrey J. Rice and Patrick S. Daugherty, Chemical Engineering, UCSB, Engineering II, Room 3357, Santa Barbara, CA 93106-5080
Targeting L-Methioninase to Human Cancer Cells
Naveen R. Palwai1, Xiao-Ping Zang2, J. Thomas Pento2 and Roger G. Harrison1, (1)School of Chemical, Biological and Materials Engineering, University of Oklahoma, 100 E. Boyd, Room T335, Norman, OK 73019, (2)Department of Pharmaceutical Sciences, University of Oklahoma, Health Sciences Center, 1110 N. Stonewall, Oklahoma City, OK 73117
Engineering Antibodies against the Epidermal Growth Factor Receptor to Block Dimerization
Ginger Chao, Mark Olsen, Alejandro Wolf-Yadlin and K. Dane Wittrup, Massachusetts Institute of Technology, 77 Massachusetts Ave. 56-478, Cambridge, MA 02139
Targeting Cd47 as an Apoptotic Trigger of Human Lung Carcinoma Tumors
Fariyal Ahmed, Shyamsundar Subramanian, M. Tewari and Dennis E. Discher, Chemical & Biomolecular Engineering, University of Pennsylvania, 220 South 33rd Street, Room 112 Towne Bldg., Philadelphia, PA 19104-6391
Intermission
Design of Effective Cancer Treatment Strategies Using Systemically Delivered Sirna: Insights from in Vivo Studies and a Mathematical Model of RNA Interference
Derek W. Bartlett, California Institute of Technology, 1200 E. California Blvd., MC 210-41, Pasadena, CA 91125 and Mark E. Davis, California Institute of Technology, Mail Code 210-41, Pasadena, CA 91125
Novel Alternating Copolymer Structures for Targeted in Vivo Imaging and Therapy in Cancer
Michelle T. Hardiman1, Jin Zhou1, Robert J. Fisher1, Clark K. Colton1, Rajesh Kumar2, Rahul Tyagi2, Virinder S. Parmar2 and Arthur C. Watterson2, (1)Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, (2)Institute for Nano-Science Engineering and Technology and Center for Advanced Materials, Departments of Chemistry and Physics, University of Massachusetts, Lowell, MA 01854
The Scale-up of T Cell Depletion for Mismatched Bone Marrow Transplants
Ying Xiong1, Xiaodong Tong1, Sherif Farag2 and Jeffrey Chalmers1, (1)Chemical and Biomolecular Engineering, The Ohio State Unversity, 140 W 19th Ave, Columbus, OH 43210, (2)Internal Medicine, The Ohio State Unversity, 140 W 19th Ave, Columbus, OH 43210

Food, Pharmaceutical & Bioengineering Division