Preliminary Program subject to change
T4004 - Synthetic Systems Biology
OverviewSystems biology is the study of whole biological ensembles, rather than isolated parts, in order to build a predictive biological understanding of a defined system’s behavior. Synthetic biology has been defined as the design and construction of systems that exhibit complex dynamical or logical behavior. The intersection between these two fields is likely to significantly enhance efforts in design-based biological engineering and therefore greatly increase human capability. This session will cover current applications of systems biology theory and techniques to aid in the design of synthetic biological systems. In addition, efforts that apply synthetic biology research as new tools to expand systems-level understanding or as new concepts in systems biology are of interest.
Primary SponsorTopical 4 - Systems Biology (T4)

Chair

Christina Smolke
Assistant Professor
Division of Chemistry & Chemical Engineering
CalTech
Pasadena, CA 91125
Phone Number: 626-395-2460
Email: smolke@cheme.caltech.edu

CoChair

Jay D. Keasling
Professor;Director, Berkeley Center for Synthetic Biology
Chemical Engineering and Bioengineering
UC, Berkeley
201 Gilman Hall
Berkeley, CA 94720-1462
Phone Number: 510-642-4862
Fax Number: 510-643-1228
Email: keasling@socrates.berkeley.edu
Construction and Evolution of an Artificial Microbial Symbiotic System
Nikos Reppas, Xiaoxia (Nina) Lin, Jay Shendure, Greg Porreca and George M. Church, Harvard Molecular Technology Group & Lipper Center for Computational Genetics, Harvard Medical School, 77 Ave. Louis Pasteur, NRB-238, Boston, MA 02115
Sources of Switch-like Behavior in Simple and Complex Biochemical Networks: Understanding the Action of a Cancer Target, Dihydrofolate Reductase
Martin R. Feinberg1, Yangzhong Tang2, Gheorghe Craciun3, Jeffrey Chalmers2 and Timothy Mitchison4, (1)Ohio State University, 140 W. 19th Avenue, Columbus, OH 43210, (2)Chemical and Biomolecular Engineering, Ohio State University, 140 W. 19th Avenue, Columbus, OH 43210, (3)Mathematics, Ohio State University, 140 W. 19th Avenue, Columbus, OH 43210, (4)Department of Systems Biology, Harvard University Medical School, 240 Longwood Avenue, Boston, MA 02115
Benefits and Costs of Improving Stress Tolerance
Jeanne M. Bonomo and Ryan T. Gill, Chemical and Biological Engineering, University of Colorado, 1111 Engineering Dr., CB 424/ ECCH 111, Boulder, CO 80309
Tuning Resistance in the Map Kinase Pathway: Lessons for Synthetic Biology from a Developmental Network in C. Elegans
Claudiu Giurumescu, Stephen Chapman and Anand R. Asthagiri, California Institute of Technology, Division of Chemistry and Chemical Engineering, Mail Code 210-41, Pasadena, CA 91125
A Synthetic E.Coli Predator-Prey System
Jun Ozaki1, Matthew Barnet2, Cynthia H. Collins2, Frances H. Arnold2 and Lingchong You1, (1)Biomedical Engineering & Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, (2)Chemistry & Chemical Engineering, California Institute of Technology, Pasadena, CA 91125
A Synthetic Gene-Metabolic Oscillator
Eileen Fung1, Wilson W. Wong2, Jason K. Suen2, Thomas Buelter2, Sungu Lee2 and James C. Liao1, (1)Chemical Engineering and Biomedical Engineering IDP, UCLA, 5531 Boelter Hall, Los Angeles, CA 90095, (2)Chemical Engineering, UCLA, 5531 Boelter Hall, Los Angeles, CA 90095
"Directed" Directed Evolution: a Simple Method for Incorporating Sequence Information to Improved Directed Evolution Experiments
Kyle L. Jensen1, Hal Alper2, Curt Fischer2 and Gregory Stephanopoulos2, (1)MIT, 66-264 MIT 77 Massachusetts Ave, Cambridge, MA 02139, (2)Chemical Engineering, MIT, 66-264 MIT 77 Massachusetts Ave, Cambridge, MA 02139

Topical 4 - Systems Biology