Preliminary Program subject to change
T8006 Protein Chromatography and Chiral Resolution of Biomolecules
OverviewThe focus of this session is to identify the latest theoretical and experimental advances in the use of chromatography for protein purification. Applications can range from large scale manufacturing to microscale proteomic applications. Topics to be covered will include, but are not limited to: Affinity chromatography, Ion exchange chromatography, Hydrophobic chromatography, Simulated moving bed chromatography, membrane chromatography, multidimensional chromatography and chip based systems.
Primary SponsorTopical 8 - Bioseparations (T8)

Chair

Steven Cramer
professor
Dept. of Chemical Engineering
RPI
110 8th Street
Troy, NY 12180
Phone Number: 518-276-f6198
Fax Number: 518-276-4030
Email: crames@rpi.edu

CoChair

Jennifer Kuehne
Research Investigator
Development Engineering
Bristol-Myers Squibb
1 Squibb Drive
New Brunswick, NJ 08690
Phone Number: 732-227-7018
Email: jennifer.kuehne@bms.com
Cartridge Filter Separation System: an Alternative to Column Chromatography in Downstream Purification of Protein Therapeutics
Masayuki Nakamura1, Kelly J. Gibbens2, Robert T. Fitzsimons2, Andrew W. Rabins2, Kannan Seshadri2, Steve M. Larsen2, Douglas A. Hanggi2, Catherine A. Bothof2, Larry J. Carson2, Gustov H. Castro2, James I. Hembre2, Patrick L. Coleman2, Jarald K. Rasmussen2 and Steven M. Heilmann2, (1)Corporate Research Lab, 3M, 3M Center, 201-2E-08, St. Paul, MN 55144, (2)3M, 3M Center, 201-2E-08, St. Paul, MN 55144
Functionalized Nanoporous Molecular Sieves for Chromatographic Separations of Proteins
Amit Katiyar, University of Cincinnati, P.O. Box 210012, Cincinnati, OH 45221-0012, Panagiotis (Peter) Smirniotis, University of Cincinnati, Chemical & Materials Engineering Department, P.O. Box 210012, Cincinnati, OH 45221-0012 and Neville G. Pinto, Chemical & Materials Engineering, University of Cincinnati, P.O. Box 210012, Cincinnati, OH 45221-0012
Protein C Purification Using Pc Specific Mini-Mab from the Inexpensive Source, Cohn Blood Plasma Fraction VI-1
Samin Rezania1, Doh Gyeuhn Ahn2 and Kyung A. Kang2, (1)University of Louisville, 106 EH Dept. of Chem. Eng., University of Louisville, Louisville, KY 40292, (2)Chemical Engineering, University of Louisville, 106 EH Dept. of Chem. Eng., University of Louisville, Louisville, KY 40292
Investigation of Protein Adsorption and Similarity Measurement for Protein Binding Behavior in Hydrophobic Interaction Chromatography (Hic) System
Jie Chen1, Qiong Luo2, Matthew C. Sundling2, Abigail H. Laurent3, Jace L. Fogle4, Yunzhi Xiao4, Curt M. Breneman2, Erik J. Fernandez4, Todd M. Przybycien3 and Steven M. Cramer1, (1)Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, 110 8th St., Troy, NY 12180, (2)Department of Chemistry, Rensselaer Polytechnic Institute, 110 8th St., Troy, NY 12180, (3)Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, (4)Department of Chemical Engineering, University of Virginia, Charlottesville, VA 22904
Intermission
Resolution of Racemic Mixtures Coupling Crystallization and Simulated Moving Bed: Fundamental Studies for S-Ketamine Production
Georgia O. F. Barros and Everson A. Miranda, Biotechnology, UNICAMP - School of Chemical Engineering, Albert Einstein St., Campinas, Brazil
Mutants of Phenylalanine Dehydrogenase: New Bio-Catalysts in the Asymmetric Synthesis and Racemic Resolution of Non-Natural Aminocids
Paul C. Engel1, Francesca Paradisi2, Eamonn Moynihan3 and Anita R. Maguire3, (1)Department of Biochemistry, University College Dublin, Conway Institute of Biomolecular and Biomedical Research, Belfield Campus, Dublin, 4, Ireland, (2)Department of Biochemistry, University College Dublin, Conway Institute, Belfield Campus, Dublin, 4, Ireland, (3)Department of Chemistry, University College Cork, Cork, Ireland
Molecular Mechanisms of Selective Sorption of Chiral Enantiometers on Amylose-Based Sorbents
Rahul B. Kasat, School of Chemical Engineering, Purdue University, 480 Stadium Mall Drive, West Lafayette, IN 47907-2100, Kendall Thomson, Purdue University, School of Chemical Engineering, 480 Stadium Mall Drive,, West Lafayette, IN 47907-2100, Hugh W. Hillhouse, Purdue University, 1283 CHME BLD, West Lafayette, IN 47907, Linda Wang, Purdue University, School of Chemical Engineering, 1283 Chemical Engineering Building, West Lafayette, IN 47907-1283 and Elias I. Franses, Purdue University, 480 Stadium Mall Drive, West Lafayette, IN 47907-2100

Topical 8 - Bioseparations