Preliminary Program subject to change
02F02 Centrifugal Field-Enhanced Bioseparations
OverviewCentrifugal force is used to enhance separation of biosolids from fluid when there is little density difference between the solids and the liquid phases, and also when very small particles or fines are present. Under these conditions, separation by gravity settling alone is generally not feasible or economical. A rapidly growing application of centrifugal field enhanced separation is the separation of protein dissolved in liquid from biosolids downstream of fermenters and bioreactors for production of therapeutic drug substances such as monoclonal antibodies. Centrifuges are also used in various steps in solid-liquid separation after precipitation and crystallization as in biopharmaceutical production. This session covers all aspects of bioseparation by centrifugation from lab-scale studies, pilot plant, to production systems using disk and tubular centrifuges. Novel designs, processes and fundamental studies on centrifugal field enhanced bioseparations will be considered. Also of interest are separation of biosolids as derived from plants for drug, fuel (ethanol) from corn, and raw materials; as well as separation in enzyme production in which decanters are used. Separation of biosolids, such as starch, using cyclones as found in food processing and other allied industries are also pertinent.
Primary SponsorFluid-Particle Separations (02f)

Chair

Wallace W.- Leung
President (*currently Chair Professor in Innovative Products & Technologies)
AdvanTech (*currently The Hong Kong Polytechnic University)
P O Box 758 (*The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong)
Sherborn, MA 01770
Phone Number: (508)-650-9196
Fax Number: (508)-650-9196
Email: wallace.leung@advantechcompany.com

CoChair

Seyi A. Odueyungbo
Senior Staff Engineer
ConocoPhillips, Inc
1000 South Pine
RW 4661
Ponca City, OK 74601
Phone Number: 580 767 3299
Fax Number: 580 767 5181
Email: Seyi.A.Odueyungbo@conocophillips.com
Simulation of Centrifugal Recovery of Protein in Biopharmaceutical Production Using Atspin Simulator
Wallace W.- Leung, AdvanTech (*The Hong Kong Polytechnic University), P O Box 758 (*The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong), Sherborn, MA 01770
Continuous Centrifugation of Adenovirus Infected Cell Culture Lysates
Jon Shanter, Michael Laska, John Konz and Hari Pujar, Biologics Development and Engineering, Merck Research Laboratories, 770 Sumneytown Pike, WP17-301, West Point, PA 19486-0004
Steps in Development of a Counter-Current Centrifugal Separator for Use in Downstream Processing
David Senica1, R.G.J.M. van der Lans2 and L.A.M. van der Wielen2, (1)Department of Biotechnology, Faculty of Applied Sciences, Delft University of Technology, Julianalaan 67, 2628 BC, Delft, Netherlands, (2)Department of Biotehnology, Faculty of Applied Sciences, Delft University of Technology, Julianalaan 67, 2628 BC, Delft, Netherlands
Experimental and Theoretical Study of Flow and Sedimentation of Tubular Centrifuge for Bioseparation
Wallace W.- Leung, AdvanTech (*The Hong Kong Polytechnic University), P O Box 758 (*The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong), Sherborn, MA 01770

Separations Division