Preliminary Program subject to change
02F03 Membrane Processes in Bioseparations
OverviewThe focus of this session is in the technologies and applications of membrane processes in bioseparation. Ultrafiltration is used extensively as a means of concentration, solvent removal and buffer exchange by diafiltration, virus removal, protein purification and fractionation. For the latter, of particular interest is in fractionation of binary proteins by exploiting the difference in the protein physical properties with respect to the membrane such as but not limited to charge, size and permeability. Also of interest are topics on concentration polarization; flux enhancement; critical flux; effect of ionic strength, pH, membrane charge on ultrafiltration; and challenging applications, such as therapeutic plasmid DNA production. New innovative applications of ultrafiltration in various bioprocessing (medical, drug, material synthesis, etc.) are also of interest. Nanofiltration finds applications, among several, such as concentation of biosuspension, removal of impurities present as monovalent ions and salts while retaining diavalent ions and salts in biosuspension. Other unique applications of nanofiltration for bioseparation are also of interest.
Primary SponsorFluid-Particle Separations (02f)

Chair

Wallace W.- Leung
President (*currently Chair Professor in Innovative Products & Technologies)
AdvanTech (*currently The Hong Kong Polytechnic University)
P O Box 758 (*The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong)
Sherborn, MA 01770
Phone Number: (508)-650-9196
Fax Number: (508)-650-9196
Email: wallace.leung@advantechcompany.com

CoChair

Vinay V. Vyas
Development Engineer, Biopharmaceutical Development Program
SAIC-Frederick, Inc., The National Cancer Institute at Frederick
P.O. Box B
Frederick, MD 21702-1201
Phone Number: (301) 846-1036
Fax Number: (301) 846-6293
Email: vvyas@ncifcrf.gov
Membrane Cascades and Intensification of Downstream Processing
E. N Lightfoot, University of Wisconsin, 1415 Engineering Drive, Madison, WI 53706
Determining Protein Fouling Parameters from Microfiltration Test
Wallace W.- Leung, AdvanTech (*The Hong Kong Polytechnic University), P O Box 758 (*The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong), Sherborn, MA 01770
Combined Models of Membrane Fouling: Development and Application to Constant Flow Microfiltration of Biological Fluids
Glen R. Bolton, Daniel LaCasse and Sal Giglia, Millipore, Bedford, MA 01730
Crossflow Microfiltration of E.Coli Cell Lysate Containing Inclusion Bodies of Recombinant Human Growth Hormone (Met-Hgh)
Adith Venkiteshwaran1, Sandro Matosevic1, Are Bogsnes2, Arne Staby2, Susan Sharfstein1 and Georges Belfort1, (1)Howard P. Isermann Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180, (2)Protein Separation, Novo Nordisk A/S, Hagedornsvej 1, 2820 Gentofte, Gentofte, Denmark
Minimization of Cell Migration between Flowing Blood and Concurrent Miscible Layers in a Microfluidic Environment
Christian P. Aucoin1, Edgar E. Nanne1, Edward F. Leonard1, Nicholas G. Vitale2 and Alan C. West1, (1)Chemical Engineering, Columbia University, 500 W. 120th St., 801 Mudd Dept of Chemical Engineering, New York, NY 10027, (2)Infoscitex Inc, Albany, NY 12205
Adsorptive Depth Filters for Virus Filtration
Willem Kools1, Daniel LaCasse2, Todd Ireland3 and Glen R. Bolton2, (1)Millipore Corporation, 80 Ashby Road, Bedford, MA 01730, (2)Millipore, Bedford, MA 01730, (3)Millipore Corporation, 900 Middlesex Tpk, Billerica, MA 01821

Separations Division