Preliminary Program subject to change
15B06 Advances in Protein Structure, Function, and Stability: Part II
OverviewThis session seeks submissions in the areas of experimental, theoretical, and computational approaches to rational prediction, design, and/or optimization of protein structure, stability, and function in laboratory and processing settings relevant to biopharmaceutical products in general. Studies may include structural analysis and engineering of proteins, creation or optimization of function, thermodynamics and dynamics of protein conformational stability, issues in folding or misfolding, degradation via physical and chemical routes, or related concerns in intracellular expression and refolding, purification, and final product formulation. Preference will be given to papers dealing with strategies that are relevant to commercial and biological systems and also provide insights into the molecular pathways or mechanisms controlling behavior.
Primary SponsorPharmaceuticals (15b)

Chair

Christopher J. Roberts
Assistant Professor
Department of Chemical Engineering
University of Delaware
Newark, DE 19716
Phone Number: 302-831-0838
Fax Number: 302-831-1048
Email: roberts@che.udel.edu

CoChair

Jeffrey J. Gray
Asst. Professor
Johns Hopkins
Chemical and Biomolecular Engineering
3400 N. Charles St.
Baltimore, MD 21218
Phone Number: (410) 516-5313
Fax Number: (410) 516-5510
Email: jgray@jhu.edu
The Effect of Various Small Heat Shock Proteins on Prevention of Beta Amyloid Aggregation and Toxicity
Sungmun Lee, Chemical and Biochemical Engineering, UMBC, 1000 Hilltop Circle, Baltimore, MD 21250 and Theresa A. Good, University of Maryland Baltimore County, 1000 Hilltop Circle, ECS 305, Baltimore, MD 21250
Identification of Inhibitory Binding Faces of ß-Amyloid Fibril Formation
Melissa A. Moss, Chemical Engineering, University of South Carolina, 2C02 Swearingen Engineering Center, Columbia, SC 29208
Cell Membrane-Mediated Amyloid-Beta Fibrillogenesis
Eva Y. Chi1, Canay Ege2 and Ka Yee C. Lee2, (1)Department of Chemistry, The Institute of Biophysical Dynamics, and the James Franck Institute, The University of Chicago, 5735 S. Ellis Ave., Chicago, IL 60637, (2)The University of Chicago, 5735 S. Ellis Ave., Chicago, IL 60637
An Improved Model of Non-Native Protein Aggregation Kinetics
Jennifer M. Andrews, University of Delaware, Colburn Laboratory, Newark, DE 19716 and Christopher J. Roberts, Department of Chemical Engineering, University of Delaware, Newark, DE 19716
Intermission
Simulation of Polyglutamine Aggregation with an Intermediate Resolution Protein Model
Alexander J. Marchut and Carol K. Hall, North Carolina State University, Box 7905, Raleigh, NC 27695
Molecular Dynamics Simulations of Surfactant-Assisted Protein Folding in Vitro
Diannan Lu, Chemical Engineering, Tsinghua University, Beijing, China, Zheng Liu, Chemical Engineering, Tsinghua University, Beijing, 100084, China and Jianzhong Wu, University of California at Riverside, Department of Chemical and Environmental Engineering, A317 Bourns Hall, Riverside, CA 92521
Reversible Changes in Protein Secondary Structure with Light Using Photoresponsive Surfactants
Shao-Chun Wang, Chemical Engineering, University of Southern California, Los Angeles, CA 90089 and C. Ted Lee Jr., University of Southern California, Los Angeles, CA 90089

Food, Pharmaceutical & Bioengineering Division