Preliminary Program subject to change
15D19 Engineering Improvements in Cancer Diagnosis and Therapy: Experimental and Computational Models
OverviewTremendous advances in biology, including but not limited to high-profile areas such as genomics and stem cells, have provided new hope for improvements in the diagnosis and treatment of cancer. Engineers have much to offer in this endeavor, in areas such as mathematical modeling (at levels ranging from whole body pharmacokinetic down to cellular and molecular dynamics), transport in tumors, development of novel drug delivery strategies and data mining. This session will highlight chemical and bio-engineering methodologies for bringing these hopes closer to practice. Studies involving modeling, experiments or both are welcome. This session will particularly highlight experimental and computational models that capture the effects of multidrug resistance, cell metabolism, cell cycle population distributions and dense three-dimensional tissue on the efficacy of cancer therapy.
Primary SponsorEngineering Fundamentals in Life Science (15d)

Chair

Charles Roth
Chemical and biochemical engineering
Rutgers University
98 Brett Road
Piscataway, NJ 08854
Phone Number: 7324453047
Email: cmroth@rci.rutgers.edu

CoChair

Neil S. Forbes
Chemical Engineering
University of Massachusetts
159 Goessmann Hall
686 North Pleasant St.
Amherst, MA 01003
Phone Number: 413-577-0132
Email: forbes@ecs.umass.edu
A Population Balance Model of Senescent Tumor Modeling and Cancer Treatment
Jeffry A. Florian Jr., Chemical and Petroleum Engineering, University of Pittsburgh, 1272 Benedum Hall, Pittsburgh, PA 15261 and Robert S. Parker, Department of Chemical and Petroleum Engineering, University of Pittsburgh, 3700 O'Hara Street, Room 1249 Benedum Hall, Pittsburgh, PA 15261
Customized Leukemia Chemotherapy Using an Age-Structured Populataion Balance
Eric Sherer, Purdue University, 1283 Forney Hall, West Lafayette, IN 47907, Doraiswami Ramkrishna, Purdue University, 480 Stadium Mall Drive, West Lafayette, IN 47907, Robert Hannemann, Purdue University, 480 Stadium Mall, West Lafayette, IN 47907 and Ann E. Rundell, Purdue University, 500 Central Drive, West Lafayette, IN 47907
A Cell Culture Analog for Multidrug Resistant Cancer Chemotherapy Screening
Daniel A. Tatosian and Michael L. Shuler, Chemical and Biomolecular Engineering, Cornell University, 120 Olin Hall, Ithaca, NY 14853
The Correlation of the Cell Cycle-Dependent Cytotoxicity and Drug Penetration into Three Dimension Tissue
Byoung-jin Kim, Univ. of Massachusetts, Amherst, 686 North Pleasant St., Amherst, MA 01003 and Neil S. Forbes, Chemical Engineering, Univ. of Massachusetts, Amherst, 686 North Pleasant St., Amherst, MA 01003
Intermission
Comparison of 3d and 2d Cell Culture Models for Toxicology Assays
Anand Kumar1, Moo-Yeal Lee2, Jonathan S. Dordick3 and Douglas S. Clark1, (1)Chemical Engineering, University of California - Berkeley, Berkeley, CA 94720, (2)Chemical Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, (3)Chemical and Biological Engineering Department, Rensselaer Polytechnic Institute, Troy, NY 12180
Metabolic Flux Analysis of Tumor Evolved Breast Cells: Effect of Estrogen Stimulation and Comparison to Normal Cells
Adam L. Meadows, University of California - Berkeley, 439 49th St Apt 9, Oakland, CA 94609, Douglas S. Clark, Chemical Engineering, University of California - Berkeley, Berkeley, CA 94720 and Harvey W. Blanch, Chemical Engineering, University of California, Berkeley, Berkeley, CA 94720-1462
Human Glioma Cells Undergoing Chemotherapy-Induced Apoptosis Exhibit Marked Reductions in Intracellular Phosphocholine and Phosphocreatine
Anthony Mancuso, Aizhi Zhu, Nancy Beardsley and Matthew Milkevitch, Radiology, University of Pennsylvania, B6 Blockley Hall/6021, 423 Gaurdian Way, Philadelphia, PA 19104-6021

Food, Pharmaceutical & Bioengineering Division