Friday, 4 November 2005 - 12:46 PM
595b
Biomimetic Surfaces for the Detection of Β-Amyloid
James E. Henry1, Dhara V. Patel
2, Mustafa Chowdhury
3, Gerard Cote
3, and Theresa A. Good
4. (1) Gordon A. & Mary Cain Department of Chemical Engineering, Louisiana State University, 110 Chemical Engineering, South Stadium Road, Baton Rouge, LA 70803, (2) University of Maryland, Baltimore County, ECS Bldg., 1000 Hilltop Cirlce, Baltimore, MD 21250, (3) Texas A&M University, 233 Zachry Engineering Center (3120 TAMU), College Station, TX 77843-3120, (4) University of Maryland Baltimore County, 1000 Hilltop Circle, ECS 305, Baltimore, MD 21250
Research indicates a strong dependence between β-amyloid toxicity and ganglioside concentration within neuronal cell membranes. Taking advantage of this relationship, we assert that it is possible to develop a biomimetic surface to be used in sensing techniques that can bind β-amyloid selectively. Furthermore, by properly developing the substrate on which the biomimetic surface is developed, it is possible to not only detect β-amyloid, but to also determine its structure (amyloid vs. random coil). We propose making this determination via surface-enhanced Raman spectroscopy (SERS).
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