Monday, 31 October 2005 - 3:55 PM
101c
Monitoring the Hydrolysis of Acetic Anhydride Using in-Situ Raman Spectroscopy and Novel Multivariate Data Analysis – Band-Target Entropy Minimization (Btem)
Effendi Widjaja, Process Science and Modeling, Institute of Chemical and Engineering Sciences, 1 Pesek Road, Jurong Island, Singapore, 627833, Singapore, Ying Yan Tan, Department of Chemical & Biomolecular Engineering, National University of Singapore, Department of Chemical & Biomolecular Engineering, 4 Engineering Drive 4, Singapore, 117576, Singapore, and
Marc Garland, Process Science and Modeling, Department of Chemical & Biomolecular Engineering, Institute of Chemical and Engineering Sciences, National University of Singapore, Department of Chemical & Biomolecular Engineering, 4 Engineering Drive 4, Singapore, 117576, Singapore.
With the increasing demand for novel process analytical technologies in recent years, Raman spectroscopy has been one of the powerful choices for in-situ reaction monitoring. In this paper, we discuss the use of in-situ Raman spectroscopy and novel multivariate data analysis method namely band-target entropy minimization (BTEM) to monitor the hydrolysis of acetic anhydride to acetic acid. In-situ Raman spectroscopy is employed to continuously measure the spectrum of reaction mixture in every 2 minutes for a few hours time. The collected spectra are then subjected to BTEM in order to elucidate the pure component spectra and the concentration profiles of the observed components. In addition, a comparison study between univariate and multivariate data analysis on the reaction spectra is also presented.
See more of #101 - Advances in Continuous Pharmaceutical Analysis and Processing (15B08)
See more of Food, Pharmaceutical & Bioengineering Division
See more of The 2005 Annual Meeting (Cincinnati, OH)