| Nonfouling and Responsive Zwitterionic Hydrogels with Improved Mechanical Properties | ||
| Zheng Zhang1, Lingyun Liu2, Timothy Chao3, Shengfu Chen4 and Shaoyi Jiang1, (1)Chemical Engineering, University of Washington, Benson Hall, Box 351750, Seattle, WA 98195, (2)Bioengineering, University of Washington, Benson Hall, Box 351750, Seattle, WA 98195, (3)Bioengineering, University of Washington, Seattle, WA 98195, (4)Chemical Engineering, University of Washington, Benson Hall, Box 351750, Seattle, WA 98195-1750 In this study, a zwitterionic hydrogels, poly(sufobetaine) methacrylate [Poly(SBMA)], was synthesized and evaluated for their applications as tissue engineering scaffolds. The cytotoxticity and endotoxicity were tested. The non-specific protein resistance was compared with those of poly(HEMA) hydrogels. In vitro tests showed that poly(SBMA) hydrogel could inhibit cell growth. In vivo implants of poly(SBMA) were also histologically evaluated and compared for the vascularity and foreign body reaction. Poly(SBMA) hydrogels are responsive to ionic strength and PH for their protein resistance, swelling and mechanical properties. Based on the responsive properties, the mechanical properties of the hydrogel were improved by a novel swelling-penetrating method. Extended Abstract Status: Not Uploaded | ||