| Protein degradation occurs throughout the life cycle of biotechnology products, and can involve a variety of physical and chemical routes. This session seeks contributions that focus at a fundamental level on the mechanism(s), kinetics, and/or quantitative modeling of one or more degradation pathways for proteins in vitro or in vivo. These may include, but are not limited to: deamidation, oxidation, proteolysis, and non-native aggregation. Priority will be given to those contributions that provide insights or applications of general use, and those that apply modern computational or theoretical tools. |
Self-Assembly, Phase Separation, and Unfolding of Coarse-Grained Proteins in Solution
Jason K. Cheung, Department of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712, Vincent K. Shen, NIST, Physical and Chemical Properties Division, 100 Bureau Dr., MS 8380, Gaithersburg, MD 20899-8380, Jeffrey R. Errington, University at Buffalo, Dept. of Chemical and Biological Engineering, 509 Furnas Hall, Buffalo, NY 14260 and Thomas M. Truskett, Chemical Engineering and Institute for Theoretical Chemistry, The University of Texas at Austin, 1 University Station, C0400, Austin, TX 78712 |
Computer Simulation of Fibril Forming Peptides with an Intermediate Resolution Protein Model
Victoria Wagoner, Chemical and Biomolecular Engineering, North Carolina State University, College of Engineering 1, Box 7905, 911 Partners Way, Raleigh, NC 27695 and Carol K. Hall, Department of Chemical and Biomolecular Engineering, North Carolina State University, College of Engineering 1, Box 7905, 911 Partners Way, Raleigh, NC 27695 |
Computing Free Energies of Peptide-Mediated Protein-Protein Interactions in Modeling Immune System Response
Jindal K. Shah, Chemical and Biomolecular Engineering, Ohio State University, Columbus, OH 43210, Dilip Asthagiri, Los Alamos National Laboratory, Group T-12, MS-B268, Los Alamos, NM 87545 and Michael E. Paulaitis, Ohio State University, 125 Koffolt Laboratories, 140 West 19'th Avenue, Columbus, OH 43210 |
Impact of Ion Hydration and Preferential Interactions on Salt-Induced Protein Deactivation Kinetics
James M. Broering, Chemical & Biomolecular Engineering, Georgia Tech, 315 Ferst Dr, Atlanta, GA 30332-0363 and Andreas S. Bommarius, Georgia Institute of Technology, School of Chemical Engineering, 315 Ferst Drive N.W., Parker H. Petit Biotechnology Institute, Room 3310, Atlanta, GA 30332-0363 |
Thermodynamics, Structure, and Oligomerization States of Key Intermediates in Non-Native Chymotrypsinogen Aggregate Initiation and Growth
Jennifer Andrews and Christopher J. Roberts, Chemical Engineering, University of Delaware, Newark, DE 19716 |
Structural Studies of the Self-Assembly and Stability of Viral Capsids
Hung D. Nguyen and Charles L. Brooks III, Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, TPC6, La Jolla, CA 92037 |
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