Preliminary Program subject to change
T2015 Advances in Protein Structure, Function, Analysis and Stability - I
OverviewThis session seeks submissions in the areas of experimental, theoretical, and computational approaches to rational prediction, design, and/or optimization of protein structure, stability, and function in laboratory and processing settings relevant to biopharmaceutical products in general. Studies may include structural analysis and engineering of proteins, creation or optimization of function, thermodynamics and dynamics of protein conformational stability, issues in folding or misfolding, degradation via physical and chemical routes, or related concerns in intracellular expression and refolding, purification, and final product formulation. Preference will be given to papers dealing with strategies that are relevant to commercial and biological systems and also provide insights into the molecular pathways or mechanisms controlling behavior.
Primary SponsorTopical 2: Discover, Development and Delivery of Medicines (T2)

Chair

Christopher J. Roberts
Assistant Professor
Department of Chemical Engineering
University of Delaware
Newark, DE 19716
Phone Number: 302-831-0838
Fax Number: 302-831-1048
Email: roberts@che.udel.edu

CoChair

Jeffrey J. Gray
Asst. Professor
Johns Hopkins
Chemical and Biomolecular Engineering
3400 N. Charles St.
Baltimore, MD 21218
Phone Number: (410) 516-5313
Fax Number: (410) 516-5510
Email: jgray@jhu.edu
A Novel Cytokine Recognition Mode in the Structure of Interleukin-2 Complexed with Its Alpha Receptor
Mathias Rickert, Cellular & Molecular Pharmacology, University of California, San Francisco, 1700 4th St., Byers Hall N508, UCSF MC 2550, San Francisco, CA 94158 and K. Chris Garcia, Stanford University, 299 Campus Dr., Fairchild Bldg, D321, Stanford, CA 94305
An Interior Water Is Essential for Maintaining the Structure of Fkbp12
Sheldon Park, Szilvia Szep, Eric T. Boder, Gregory Van Duyne and Jeffery G. Saven, University of Pennsylvania, Philadelphia, PA 19104
Binding Site Allostery in the E. Coli Groel Chaperonin Subunit
Yelena R. Sliozberg, Drexel University, 3141 Chestnut street, Philadelphia, PA 19104 and Cameron F. Abrams, Drexel University, Department of Chemical Engineering, Philadelphia, PA 19104
Local Motions in Allosteric Proteins
Michael Daily, Program in Molecular & Computational Biophysics, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218 and Jeffrey J. Gray, Johns Hopkins, Chemical and Biomolecular Engineering, 3400 N. Charles St., Baltimore, MD 21218
A Novel Approach for Alpha-Helical Topology Prediction in Globular Proteins
Scott R. McAllister, Chemical Engineering, Princeton University, Dept of Chemical Engineering; A215 Engineering Quadrangle, Princeton, NJ 08544 and Christodoulos A. Floudas, Chemical Engineering, Princeton University, Princeton, NJ 08544
An Antibody Loop Replacement Design Feasibility Study and a Loop-Swapped Dimer Structure
Louis A. Clark, Biogen Idec, 14 Cambridge ctr, Cambridge, MA 02142
A Branch-and-Reduce Algorithm for the Contact Overlap Problem
Wei Xie, Chemical and Biomolecular Engineering, University of Illinois, 600 South Mathews Avenue, Urbana, IL 61801 and Nick Sahinidis, University of Illinois, Department of Chemical and Biomolecular Engineering, 600 South Mathews Avenue, Urbana, IL 61801

Topical 2: Discovery, Development and Delivery of Medicines