Preliminary Program subject to change
15C05 Systems Biotechnology
OverviewSystems biotechnology involves understanding the control and cellular dynamics of multiple genes/proteins/small molecules. Typically, a systems biology study involves global measurements on changes in gene, protein or metabolite concentrations in response to environmental or genetic perturbation. The forefront of this research area combines several of these techniques with mathematical modeling to uncover the features leading to phenotypes such as sensitivity or robustness. Possible topics include analysis of intracellular signal transduction, metabolic pathways, cell cycle, circadian rhythms, quorum sensing. Biological systems from single cell microbes to mammalian tissues will be considered.
Primary SponsorBioengineering (15c)

Chair

John A. Morgan
Assistant Professor
School of Chemical Engineering
Purdue University
480 Stadium Mall Dr.
1160 FRNY,
West Lafayette, IN 47907
Phone Number: 765-494-4088
Fax Number: 765-494-0805
Email: jamorgan@purdue.edu
Systematic Investigation of E. Coli Ai-2 Quorum Sensing Circuit Reveals Alternative Synthesis Pathways
Jun Li, Center for Biosystem Research & Chemical and Biomolecular Department, University of Maryland, College Park, MD 20742, Liang Wang, University of Maryland Biotechnology Institute, College Park, College Park, MD 20742, Yoshifumi Hashimoto, University of Maryland, College Park, 6143 Plant Science Bldg, College Park, MD 20742, Chenyu Tsao, University of Maryland Biotechnology Institute, College Park, 6142 Plant Science building, Univeristy of Maryland, College Park, MD 20742, Thomas K. Wood, Artie McFerrin Department of Chemical Engineering, Texas A&M University, 200 Jack E. Brown Building, MS 3122, College Station, TX 77843-3122 and William E. Bentley, Center for Biosystem Research & Chemical and Biomolecular Engineering Department, University of Maryland Biotechnology Institute, College Park, 6140 Plant Science building, Univeristy of Maryland, College Park, MD 20742
Exploiting Transcriptional Patterns of Antibiotic Activity for Treatment Optimization and Development
Zhigang Zhang, Chemical Engineering and Materials Science, and BioTechnology Institute, University of Minnesota, 1479 Gortner Ave., Room 140, St Paul, MN 55108, Friedrich Srienc, Department of Chemical Engineering and Materials Science, and BioTechnology Institute, University of Minnesota, 1479 Gortner Ave., Room 240, St. Paul, MN 55108 and Arkady Khodursky, Department of Biochemistry, Molecular Biology and Biophysics, and BioTechnology Institute, University of Minnesota, 1479 Gortner Ave., Room 140, St Paul, MN 55108
Chemogenomic Deduction of Escherichia coli's Nitric Oxide Response Network
Daniel R. Hyduke, Laura R. Jarboe, Linh M. Tran and James C. Liao, Chemical & Biomolecular Engineering, UCLA, 5531 Boelter Hall, 420 Westwood Pl, Los Angeles, CA 90095
Signaling Pathways Affecting Sporulation and Stationary Phase Phenomena in Clostridium Acetobutylicum
Ryan Sillers1, Mohab Al-Hinai2, Carlos J. Paredes1 and Eleftherios T. Papoutsakis1, (1)Chemical and Biological Engineering, Northwestern University, 2145 N. Sheridan Rd., Tech E136, Evanston, IL 60208, (2)Biology Department, Sultan Qaboos University, PO Box 36, Muscat 123, Oman
Break
Transcriptional Regulation Underlying the Central Nervous System Response to Acute Hypertension
Rajanikanth Vadigepalli, Rishi Khan and James S. Schwaber, Daniel Baugh Institute for Functional Genomics and Computational Biology, Thomas Jefferson University, 1020 Locust St Room 575, Philadelphia, PA 19107
Comparative Transcriptome Analysis of Stem Cell Populations Expressing Varying Levels of the Transcription Factor Oct-4
Fernando Ulloa-Montoya1, Catherine Verfaillie2 and Wei-Shou Hu1, (1)Chemical Engineering and Materials Science, University of Minnesota, 151 Amundson Hall, 421 Washington Avenue SE, Minneapolis, MN 55455-0132, (2)Stem Cell Institute and Department of Medicine, University of Minnesota, Minneapolis, MN
Comprehensive Analysis of the Gluconeogenesis Pathways through the Combined Use of Multiple Isotopic Tracers
Maciek R. Antoniewicz1, Jose Aleman1, Joanne K Kelleher1 and Gregory N. Stephanopoulos2, (1)MIT, 77 Massachusetts Avenue, room 56-439, Cambridge, MA 02139, (2)Department of Chemical Engineering, MIT, 77 Massachusetts Avenue, room 56-439, Cambridge, MA 02139

Food, Pharmaceutical & Bioengineering Division