| This session will focus on recent developments in the field of cell culture with emphasis on application in therapeutic protein productivity enhancement. Methods for improving the performance of cell culture processes, including media development, process parameter adjustments, and scale up/scale down methods, as well as the effect of these methods on product quality, will be emphasized. Additionally, innovations in cell culture technology, including sensors and analyzer technology, as well as bioreactor and control systems may be showcased. Potential audience of the session include students as well as scientists and engineers from academia and biotech industry involved in cell culture process R&D. |
Increasing Adeno-Associated Virus Specific Yield in Insect Cell Culture by Increasing Temperature
Marc G. Aucoin1, Michel Perrier2 and Amine A. Kamen1, (1)Animal Cell Technology, National Research Council, 6100 Royalmount Ave, Montreal, QC H4P2R2, Canada, (2)Chemical Engineering, Ecole Polytechnique de Montreal, Campus de l'Université de Montréal, 2500, chemin de Polytechnique, Montreal, QC H3T 1J4, Canada |
Antibody Production in the GS-NS0 System under Normal and Hyperosmotic Culture Conditions: a Combined Modeling and Experimental Study
Yingswan Ho, Julie Varley and Athanasios Mantalaris, Department of Chemical Engineering and Chemical Technology, Imperial College London, South Kensington Campus, London, SW7 2AZ, United Kingdom |
Implementation of Online Amino Acid Analysis for Medium and Feed Optimization in Mammalian Cell Culture
Polina Rapoport, Michael S. Arulgnanendran, Melinda Krebs, Martin Gawlitzek, Kirin Malik Jamison and Deborah E. Pascoe, Late Stage Cell Culture BioProcess Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080 |
Automated Flow Cytometry for Monitoring and Control of Cho Cell Cultures
Greg Sitton, Alan Gilbert, Ann Hansgate and Friedrich Srienc, Biotechnology Institute / Chemical Engineering, University of Minnesota, 1479 Gortner Ave, 140 Gortner Labs, St Paul, MN 55108 |
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Rapid and Efficient Strain Evaluation Using a Micro-Scale Bioreactor
Janine Reimann, Gopal Chotani, Tim Dodge and Alfred Gaertner, Danisco Genencor, 925 Page Mill Road, Palo Alto, CA 94304 |
The Use of Energy Dissipation Rate as a Parameter to Assist in the Evaluation, Scale-up, and Scale-down of Bioprocesses
Jeffrey J. Chalmers1, Ruben Godoy2 and Claudia Berdugo2, (1)Chemical and Biomolecular Engineering, The Ohio State University, 125 Koffolt Labs, 140 W. 19th Ave., Columbus, OH 43210, (2)The Ohio State University, 125 Koffolt Labs, 140 W. 19th Ave., Columbus, OH 43210 |
Evaluating Biopharmaceutical Economics and Capacity with Process Modeling and Simulation Tools
Demetri P. Petrides, INTELLIGEN, INC., 2326 Morse Avenue, Scotch Plains, NJ 07076 and Charles Siletti, INTELLIGEN, INC., 700 Walton Ave., Mount Laurel, NJ 08054 |
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