Preliminary Program subject to change
15C11 Advances in Protein Engineering (II)
OverviewThe focus of this session is to reflect the latest advances in protein engineering and design. Suggested topics include, but are not limited to: (1) Development of high throughput screen/selection for protein engineering; (2)Development of novel protein engineering methods; (3) Protein engineering via directed evolution; (4) Structure- or sequence-based and computational protein engineering and design; (5) Applications of protein engineering.
Primary SponsorBioengineering (15c)
Co-Sponsor(s)Catalysis and Reaction Engineering Division (20)

Chair

Lianhong Sun
Assistant Professor
Department of Chemical Engineering
University of Massachusetts Amherst
686 N. Pleasant Street
Amherst, MA 01003
Phone Number: 413-545-6143
Fax Number: 413-545-1647
Email: lsun@ecs.umass.edu

CoChair

Scott Banta
Chemical Engineering
Columbia University
500 W 120th St
New York, NY 10027
Phone Number: 212-854-7531
Email: sbanta@cheme.columbia.edu
Adapting Proteins to Accommodate Unnatural Amino Acids
Tae Hyeon Yoo, A. James Link and David A. Tirrell, Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E. California Blvd., MC 210-41, Pasadena, CA 91125
High Affinity Fn3 Domains Using Loop Length Diversity and Population Maturation
Benjamin J. Hackel, Chemical Engineering, Massachusetts Institute of Technology, 50 Ames Street, E19-563, Cambridge, MA 02139 and K. Dane Wittrup, Chemical Engineering and Biological Engineering, Massachusetts Institute of Technology, 50 Ames Street, E19-563, Cambridge, MA 02139
A Peptide Inhibitor Reveals an Extended Conformation of Transglutaminase 2
Daniel M. Pinkas1, Pavel Strop2 and Chaitan Khosla1, (1)Chemical Engineering, Stanford University, 381 North-South Mall, Stanford, CA 94305, (2)Howard Hughes Medical Institute and Molecular and Cellular Physiology, Stanford University, James H. Clark Center E300, 318 Campus Drive, Stanford, CA 94305
Directed Evolution of the Luxr Transcription Factor for Applications in Synthetic Biology
Daniel J. Sayut1, Yan Niu1, Cheng Yuk Lee1, Pavan Kumarreddy Kambam1 and Lianhong Sun2, (1)Chemical Engineering, University of Massachusetts, 159 Goessmann Laboratory, 686 North Pleasant St, Amherst, MA 01003, (2)Department of Chemical Engineering, University of Massachusetts Amherst, 686 N. Pleasant Street, Amherst, MA 01003
Break
Engineering of a Carbazole Denitrogenation Pathway through Directed Evolution
Ee Lui Ang, Department of Chemical and Biomolecular Engineering, National University of Singapore, Blk E5-02-11, 4 Engineering Drive 4, Singapore, Singapore, Jeffrey P. Obbard, Division of Environmental Science and Engineering, National University of Singapore, Blk E2-05-17, 5 Engineering Drive 2, Singapore, Singapore and Huimin Zhao, University of Illinois, 215 Roger Adams Lab, Box C3, 600 S. Mathews Ave., Urbana, IL 61801
A Optimized Chimeric Estrogen-Sensor Protein: Applications in Drug Discovery and Biosensing
David W. Wood, Princeton University, A213 EQUAD, Princeton, NJ 08544 and Georgios Skretas, Chemical Engineering, Princeton University, A213 EQUAD, Princeton, NJ 08544
Engineering of Blue Fluorescent Protein by Coupling Computational Design and Combinatorial Screening
Marco A. Mena1, Thomas P. Treynor2, Stephen L. Mayo2 and Patrick S. Daugherty1, (1)Department of Chemical Engineering, UC Santa Barbara, Engineering II Rm 3357, Santa Barbara, CA 93106-5080, (2)Division of Biology, Division of Chemistry and Chemical Engineering, California Institute of Technology, Caltech 114-96, 1200 E. California Blvd, Pasadena, CA 91125-9600

Food, Pharmaceutical & Bioengineering Division