Preliminary Program subject to change
15E00 Receptor Mediated Phenomena
OverviewReceptor mediated phenomena are important mechanisms by which cells communicate with their environment. In this session, we are seeking papers which examine a variety of receptor mediated phenomena, associated with such processes as intracellular signaling, cell-cell signaling, mechanotransduction, or tissue remodeling for example. Of particular interest are studies involving receptor mobility and clustering. Modeling and experimental approaches to examining receptor mediated phenomena are welcome.
Primary SponsorEngineering Fundamentals in Life Science (15e)

Chair

Michael R. King
Assistant Professor
University of Rochester
Department of Chemical Engineering
311A Towne Bldg., 220 South 33rd Street
Rochester, NY 14642
Phone Number: (585) 275-3285
Fax Number: (585) 273-4746
Email: mike_king@urmc.rochester.edu

CoChair

Cynthia Reinhart-King
Assistant Professor
Department of Biomedical Engineering
Cornell University
Rochester, NY 14642
Phone Number: 585-275-1234
Email: creinhar@seas.upenn.edu
Integrated Models of Leukocyte Signaling and Adhesion
Daniel A. Hammer1, Kelly E. Caputo2, Ellen Krasik1 and Michael Beste2, (1)University of Pennsylvania, Department of Bioengineering, 120 Hayden Hall, 3320 Smith Walk, Philadelphia, PA 19104, (2)Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104
Manganese and Gadolinum Regulate Neutrophil Cd18 Integrin Affinity Via Distinct Mechanisms
Sriram Neelamegham1, Yi Zhang1, Heather N. Hayenga2, Melissa R Sarantos3 and Scott I. Simon3, (1)Chemical And Biological Engineering, State University of New York at Buffalo, 303 Furnas Hall, North Campus, Amherst, NY 14226, (2)Department of Biomedical Engineering, University of California, Davis, CA, (3)Biomedical Engineering, University of California, Davis, CA
Elucidating the Sequential Binding of Lfa-1 and Mac-1 to Icam-1 under Shear Conditions: Possible Role of E-Selectin Signaling
A. Omolola Eniola, Chemical Engineering, University of Michigan, 2300 Hayward St., 3074 H.H. Dow Building, Ann Arbor, MI 48109 and C. Wayne Smith, Pediatrics/Section of Leukocyte Biology, Baylor College of Medicine, Children s Nutrition Research Center, Suite 6014, 1100 Bates, Houston, TX 77030
Spontaneous Activation of Pi 3-Kinase Signaling during Fibroblast Spreading Is Affected by Surface Rigidity and Cytoskeletal Signaling Components
Michael Weiger, Chemical & Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695-7905 and Jason Haugh, Chemical & Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695
Break
Experimental and Computational Analysis of Notch1 Receptor Signaling in Adult Neural Stem Cell Differentiation
Smita Agrawal, University of California, Berkeley, 201 Gilman Hall, UC Berkeley, Berkeley, CA 94720 and David V. Schaffer, Chemical Engineering, University of California, Berkeley, 201 Gilman Hall, UC Berkeley, Berkeley, CA 94720
Autologous Chemotaxis of Tumor Cells: a Novel Homing Mechanism to Lymphatics
Mark E. Fleury, Jacqueline D. Shields, Alice A. Tomei and Melody A. Swartz, Integrative Biosciences Institute, Ecole Polytechnique Federale de Lausanne (EPFL), Bat AAB231 Station 15, Lausanne, 1015, Switzerland
Autocatalytic Activation of a Viral Fusion Protein
Jeong H. Lee1, Mark Goulian2 and Eric T. Boder1, (1)Chemical and Biomolecular Engineering, University of Pennsylvania, 220 South 33rd Street, Philadelphia, PA 19104, (2)Physics, University of Pennsylvania, 220 South 33rd Street, Philadelphia, PA 19104

Food, Pharmaceutical & Bioengineering Division