Preliminary Program subject to change
15D05 Drug Delivery (I)
OverviewThis session highlights recent research efforts in the broad area of design, characterization (in vitro and in vivo), and development of drug delivery systems with multi-functional properties for targeted and sustained drug delivery. Topics of interest include, but are not limited to: Effects of chemical structure and/or physical properties of drug delivery systems on loading efficiency and release kinetics; functionalizing drug carriers with moieties for specific targeting; blood circulation time and biodistribution of drug-carrier complexes after systemic injection; in vitro and in vivo studies of cellular uptake.
Primary SponsorEngineering Fundamentals in Life Science (15d)

Chair

Efrosini Kokkoli
Department of Chemical Engineering and Materials Science
University of Minnesota
Minneapolis, MN 55455
Phone Number: 612-626-1185
Fax Number: 612-626-7246
Email: kokkoli@cems.umn.edu

CoChair

Stavroula Sofou
Polytechnic University
Department: Chemical and Biological Sciences and Engineering
Room RH 729A, 6 MetroTech Center
Brooklyn, NY 11201
Phone Number: (718) 260-3863
Fax Number: (718) 260-3125
Email: ssofou@duke.poly.edu
Design of Targeted Nanocarriers for Optimal Drug Delivery to Stressed Endothelium: a Multiscale Modeling Approach
Joshua Weinstein, Department of Physics, University of Pennsylvania, 120 Hayden Hall, 3320 Smithwalk, Philadelphia, PA 19104, Neeraj Agarwal, Chemical and Biomolecular Engineering, University of Pennsylvania, 120 Hayden Hall, 3320 Smithwalk, Philadelphia, PA 19104 and Ravi Radhakrishnan, Department of Bioengineering, University of Pennsylvania, 120 Hayden Hall, 3320 Smithwalk, Philadelphia, PA 19104
Comparative Analysis of the Uptake and Intracellular Fate of Nanoparticles in Different Epithelial Cell Types
Malgorzata S. Cartiera1, K. M. Johnson1, V. Rajendran2, M. J. Caplan2 and W. Mark Saltzman1, (1)Biomedical Engineering, Yale University, 55 Prospect St., MEC 414, New Haven, CT 06520, (2)Cell and Molecular Physiology, Yale University, School of Medicine, 333 Cedar Street, SHM B-116/117, New Haven, CT 06520
Efficient Sirna Delivery with Acetylated Polyethylenimine
Lily Wong, Chemical and Biomolecular Engineering, University of Illinois, Box C-3, 600 S. Mathews Ave, Urbana, IL 61801 and Daniel W. Pack, Chemical and Biomolecular Engineering, University of Illinois, Box C-3, 600 S. Mathews Ave., Urbana, IL 61801
Biodegradable Spray Dried Microspheres and Discs Delivering Paclitaxel and Etanidazole for the Treatment of Giloma: an in Vivo Subcutaneous Study
Benjamin Y. S. Ong, Department of Chemical & Biomolecular Engineering, National University of Singapore / University of Illinois at Urbana-Champaign, 4 Engineering Drive 4, Singapore, Singapore, 117576, Singapore, Pavan Kumar Naraharisetti, MEBCS Program, Singapore-MIT Alliance, 4 Engineering Drive 3, Singapore, 117576, Singapore, Jingwei Xie, Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore, 117576, Singapore, Chi-Hwa Wang, National University of Singapore, Department of Chemical and Biomolecular Engineering, Singapore, 117576, Singapore and Nick Sahinidis, University of Illinois, Department of Chemical and Biomolecular Engineering, 600 South Mathews Avenue, Urbana, IL 61801
Break
Coated Microneedles for Transdermal Drug Delivery
Harvinder S. Gill, Biomedical Engineering, Georgia Institute of Technology, 315 Ferst Drive, Atlanta, GA 30332 and Mark R. Prausnitz, Chemical and Biomolecular Engineering, Biomedical Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA 30332-0100
A Biodegradable Fiber for Controlled Delivery of Therapeutics to the Eye
Brendan C. Mack1, Kenneth W. Wright2 and Mark E. Davis1, (1)Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, (2)Pediatric Ophthalmology, Cedars-Sinai Medical Center, Los Angeles, CA 90048
Drug Elimination Kinetics in the Eye after Subconjunctival Delivery
Stephanie H. Kim, Chemical Engineering, University of Maryland and NIH, 13 South Drive, Bldg 13 / 3N07, Bethesda, MD 20892, Robert J. Lutz, Division of Bioengineering and Physical Science, National Institutes of Health, 13 South Drive, Bldg 13 / 3N17, Bethesda, MD 20892, Karl G. Csaky, National Eye Institute, National Institutes of Health, 13 South Drive, Bldg 10 / 10B11, Bethesda, MD 20892, Craig J. Galban, Division of Bioengineering and Physical Science, National Institutes of Health, 13 South Drive, Bldg 13 / 3N05, Bethesda, MD 20892 and Nam Sun Wang, Chemical Engineering, University of Maryland, College Park, MD 20742

Food, Pharmaceutical & Bioengineering Division