Preliminary Program subject to change
15C15 Advances in Metabolic Engineering and Bioinformatics (I)
OverviewThis session will focus on Metabolic Engineering as a molecular-systems approach to the understanding and utilization of metabolic processes. The goal of the session is to discuss very recent advances in modeling and experimental approaches necessary to understand the integration and control of genetic, catalytic, and other biochemical events that govern cellular metabolism. Topics of interest include: reconstruction of metabolic as well as gene regulatory networks; control analysis; genomic, proteomic and/or metabolomic analysis; optimization; and heterologous pathways. We invite papers on the development and application of these techniques to cells derived from plant, insect, and animal tissues.
Primary SponsorBioengineering (15c)

Chair

Kyongbum Lee
Assistant Professor
Tufts University
4 Colby Street
Room 142
Medford, MA 02155
Phone Number: 617-627-4323
Fax Number: 617-627-3991
Email: kyongbum.lee@tufts.edu

CoChair

Christina Chan
Associate Professor
Chemical Engineering and Material Science
Michigan State University
2527 Engineering Building
East Lansing, MI 48824
Phone Number: (517) 432-4530
Fax Number: (517) 432-1105
Email: krischan@egr.msu.edu
Elementary Metabolite Units (Emu): a Novel Framework for Modeling Isotopic Tracer Distributions and Determining Metabolic Fluxes
Maciek R. Antoniewicz1, Jose Aleman1, Joanne K Kelleher1 and Gregory N. Stephanopoulos2, (1)MIT, 77 Massachusetts Avenue, room 56-439, Cambridge, MA 02139, (2)Department of Chemical Engineering, MIT, 77 Massachusetts Avenue, room 56-439, Cambridge, MA 02139
Genome-Scale Metabolic Systems Design by Flux Transition Theory
Matthew L. Rizk and James C. Liao, Chemical and Biomolecular Engineering, University of California, Los Angeles, 5531 Boelter Hall, 420 Westwood Plaza, Los Angeles, CA 90095
Reconstitute Biosynthesis of Tetracycline Intermediates
Wenjun Zhang, Chemical and Biomolecular Engineering, University of California at Los Angeles, 420 Westwood Plaza, 5667 Boelter Hall, Los angeles, CA 90095 and Yi Tang, Chemical and Biomolecular Engineering, University of California at Los Angeles, 420 Westwood Plaza, 5667 Boelter Hall, Los Angeles, CA 90095
Transcriptomic Studies of an Amorphadiene Producing E. Coli Strain in an Acka/Pta/Poxb Deletion Background
Robert H. Dahl II, Yisheng Kang and Jay D. Keasling, Chemical Engineering, University of California, Berkeley, 201 Gilman Hall, Berkeley, CA 94720
Break
Characterization of Poly(3-Hydroxybutyrate-Co-3-Hydroxyvalerate) Production in Escherichia Coli
Matthew S. Wong1, Thomas B. Causey2, Nikos Mantzaris3, George N. Bennett2 and Ka-Yiu San1, (1)Bioengineering, Rice University, 6100 Main Street MS#142, Houston, TX 77005, (2)Biochemistry & Cell Biology, Rice University, 6100 Main Street MS#140, Houston, TX 77005, (3)Chemical & Biomolecular Engineering, Rice University, 6100 Main Street MS#362, Houston, TX 77005
Metabolic Engineering of E. Coli for Alpha-Gal Epitope Synthesis
Zichao Mao, School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Dr. NW, Atlanta, GA 30332-0100, Anne Ruffing, Chemical and Biomolecular Engineering, Georgia Institute of Technology, 778 Atlantic Dr., Atlanta, GA 30332 and Rachel Ruizhen Chen, School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 778 Atlantic Dr, Atlanta, GA 30332
Natural and Unnatural Flavonoid Biosynthesis and Their Insulinotropic Properties in Pancreatic Beta Cells
Lye T. Lock1, Effendi Leonard2, Yajun Yan2, Joseph Chemler2, Manolis S. Tzanakakis3 and Mattheos Koffas2, (1)Chemical and Biological Engineering, State University of New York at Buffalo, 1015 Furnas Hall, Buffalo, NY 14260, (2)Chemical and Biological Engineering, University at Buffalo, the State University of New York, 914 Furnas Hall, Buffalo, NY 14260, (3)Chemical and Biological Engineering, State University of New York at Buffalo, 907 Furnas Hall, Buffalo, NY 14260

Food, Pharmaceutical & Bioengineering Division