Preliminary Program subject to change
TA002 Proteomic Systems Biology
OverviewWith high-throughput proteomic and metabolomic technology becoming so prevalent, the natural next question is how to make use of such information. The goal for this session is to discuss how and where proteomic and metabolomic technology is being used to advance or complement our understanding of systems biology. Likewise, is systems biology informing our approach to proteomics and metabolomics? Research describing the development and testing of new hypotheses, as well as describing new techniques, are welcome.
Primary SponsorTopical A: Systems Biology (TA)

Chair

Eric Shusta
Assistant Professor
University of Wisconsin
1415 Engineering Drive
Madison, WI 53715
Phone Number: (608) 265-5103
Email: shusta@engr.wisc.edu

CoChair

Eric T. Boder
Chemical & Biomolecular Engineering
University of Pennsylvania
220 South 33rd Street
Room 112 Towne Bldg.
Philadelphia, PA 19104-6391
Phone Number: 215-573-0743
Email: boder@seas.upenn.edu
A Model for Protein Translation: Polysome Self-Organization Leads to Maximum Protein Synthesis Rates
Hermioni Zouridis and Vassily Hatzimanikatis, Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Rd., Evanston, IL 60208
Protein Structure and Fold Recognition Using Amino Acid Interaction Models
Raghuraj K. Rao and Lakshminarayanan Samavedham, Chemical and Biomolecular Engineering, National University of Singapore, 4, Engineering Drive 4, Singapore, 117576, Singapore
Using Atomic Properties to Identify Potential Reactants in Oxidoreductase Reactions
Fangping Mu1, Pat J. Unkefer2, Clifford J. Unkefer2 and William S. Hlavacek1, (1)Theoretical Biology and Biophysics Group, Theoretical Division, Los Alamos National Laboratory, T-10, MS710, Los Alamos, NM 87544, (2)National Stable Isotope Resource, Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87544
Initiation of Blood Coagulation: a Systems Biology Approach
William S. Denney and Scott L. Diamond, Chemical and Biomolecular Engineering, University of Pennsylvania, 1150 Vagelos Labs, 3340 Smith Walk, Philadelphia, PA 19104
Break
Proteome Changes after Metabolic Engineering to Enhance Aerobic Mineralization of Cis-1,2-Dichloroethylene
Jintae Lee1, Cao Li1, Saw Yen Ow2, Martin E. Barrios-Llerena2, Wilfred Chen3, Thomas K. Wood1 and Phillip C. Wright2, (1)Artie McFerrin Department of Chemical Engineering, Texas A&M University, 200 Jack E. Brown Building, MS 3122, College Station, TX 77843-3122, (2)Department of Chemical and Process Engineering, The University of Sheffield, Biological & Environmental Systems Group, Sheffield, S1 3JD, United Kingdom, (3)Chemical and Environmental Engineering, University of California, Riverside, Bourns Hall A242, University of California, Riverside, Riverside, CA 92521
De Novo Protein Design with Flexible Templates and Its Application to the Redesign of Complement 3a
Ho Ki Fung1, Christodoulos A. Floudas1, Dimitrios Morikis2, John D. Lambris3 and Li Zhang4, (1)Department of Chemical Engineering, Princeton University, Engineering Quadrangle, Olden Street, Princeton, NJ 08544, (2)Department of Chemical and Environmental Engineering, University of California at Riverside, A319 Bourns Hall, Riverside, CA 92521, (3)Department of Pathology and Laboratory Medicine, University of Pennsylvania, 401 Stellar Chance, Philadelphia, PA 19104, (4)Department of Chemistry, University of California at Riverside, University of California at Riverside, Riverside, CA 92521
Integrated Time-Series Metabolomic and Transcriptional Profiling Analyses of Arabidopsis Thaliana Response to Elevated Co2 and Osmotic Stress
Bhaskar Dutta1, Harin H. Kanani1, John Quackenbush2 and Maria I. Klapa1, (1)Department of Chemical and Biomolecular Engineering, University of Maryland, 2113 Chemical and Nuclear Engineering Building, College Park, MD 20742-2111, (2)Department of Biostatistics, Dana-Farber Cancer Institute, Mayer 232, 44 Binney Street, Boston, MA 02115

Topical A: Systems Biology