Preliminary Program subject to change
TA003 Metabolomic Approaches to Systems Biology
OverviewWith high-throughput metabolomic technology becoming so prevalent, the natural next question is how to make use of such information. The goal for this session is to discuss how and where metabolomic technology is being used to advance or complement our understanding of systems biology. Likewise, is systems biology informing our approach to metabolomics? Research describing the development and testing of new hypotheses, as well as describing new techniques relating metabolomics and systems biology are welcome.
Primary SponsorTopical A: Systems Biology (TA)

Chair

Patrick C. Cirino
Assistant Professor
Penn State University
120 Fenske Lab
University Park, PA 16802
Phone Number: 814-865-5790
Fax Number: 814-865-7846
Email: cirino@engr.psu.edu

* Membership Number 0000155622

CoChair

Phillip C. Wright
Professor and EPSRC Advanced Research Fellow
The University of Sheffield
Biological & Environmental Systems Group
Department of Chemical and Process Engineering, Mappin Street
Sheffield, S1 3JD
UK
Phone Number: (0)1142227577
Fax Number: (0)1142227501
Email: p.c.wright@sheffield.ac.uk
Increasing the in Vivo Nadph Availability by Metabolic Engineering in Escherichia Coli
Irene Martinez, Department of Bioengineering, Rice University, 6100 Main St. MS 142, PO Box 1892, Houston, TX 77005, Jiangfeng Zhu, Department of Bioengineering, Rice University, Houston, TX 77005, Henry Lin, Department of Bioengineering, Rice University, 6100 Main St., MS 142, PO Box 1892, Houston, TX 77005, George N. Bennett, Biochemistry and Cell Biology, Rice University, 6100 Main st, Houston, TX 77005 and Ka-Yiu San, Department of Bioengineering, Rice University, MS-142, PO Box 1892, Houston, TX 77005
Elucidating the Mode of Cytotoxicity in an Escherichia Coli Strain Engineered for Isoprenoid Production Using Transcriptomics and Metabolite Profiling
Lance Kizer, Chemical Engineering, University of California, Berkeley, 717 Potter St., Bldg 977, Berkeley, CA 94720, Douglas J. Pitera, Amyris Biotechnologies, 5980 Horton St, Suite 450, Emeryville, CA 94608, Brian Pfleger, University of California, Berkeley, Berkeley, CA 94720 and Jay D. Keasling, Department of Chemical Engineering, University of California, Berkeley, 201 Gilman Hall, Berkeley, CA 94720
Metabolic Profile-Based Analysis of Metabolic Network Modularity
Jeongah Yoon, Chemical and Biological Engineering, Tufts University, 4 Colby Street, Rm 234, Medford, MA 02155, Yaguang Si, Biology, Tufts University, 4 Colby Street, Room 142, Medford, MA 02155 and Kyongbum Lee, Tufts University, 4 Colby Street, Room 142, Medford, MA 02155
Systematic Identification of Conserved Metabolites in Gc-MS Data for Metabolomics and Biomarker Discovery
Mark Styczynski1, Joel Moxley2, Lily V. Tong3, Jason L. Walther4 and Gregory N. Stephanopoulos4, (1)Chemical Engineering, MIT, 66-264 MIT 77 Massachusetts Ave, Cambridge, MA 02139, (2)Chemical Engineering, MIT, 77 Massachusetts Ave, Cambridge, MA 02139, (3)Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave., 56-439, Cambridge, MA 02139, (4)Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave., 56-439, Cambridge, MA 02139
Accurate Time-Series Metabolomic Analysis of a Systematically Perturbed Arabidopsis Thaliana Liquid Culture System for Studying Regulation of Plant Primary Metabolism
Harin H. Kanani and Maria I. Klapa, University of Maryland, 2113 Chemical and Nuclear Engineering Building, College Park, MD 20742-2111
Flux and Transcriptome Alterations in Mammalian Glycerol Kinase Disorders
Ganesh Sriram1, Lola Rahib2, Jian-Sen He3, Allison Campos3, Lilly Parr3, James C. Liao4 and Katrina M. Dipple5, (1)Human Genetics & Chemical Engineering, University of California, Los Angeles, 695 Charles E. Young Dr. S. #5335, Los Angeles, CA 90095, (2)Bioengineering, University of California, Los Angeles, 695 Charles E. Young Dr. S. #5335, Los Angeles, CA 90095, (3)Human Genetics, University of California, Los Angeles, 695 Charles E. Young Dr. S. #5335, Los Angeles, CA 90095, (4)Chemical and Biomolecular Engineering, University of California, Los Angeles, 5531 Boelter Hall, 420 Westwood Plaza, Los Angeles, CA 90095, (5)Human Genetics & Pediatrics - David Geffen School of Medicine, University of California, Los Angeles, 695 Charles E. Young Dr. S. #5335, Los Angeles, CA 90095
Effect of YfiD and PoxB Gene Disruption on Microaerobic Pyruvate Catabolization and Metabolic Flux Distributions Based on C-13 Labeling Experiments
Jiangfeng Zhu1, Sagit Shalel-Levanon2, George N. Bennett3 and Ka-Yiu San1, (1)Department of Bioengineering, Rice University, Houston, TX 77005, (2)Department of Biotechnology and Food Engineering, Technion- Israel Institute of Technology, Technion City, Israel, (3)Department of Biochemistry & Cell Biology, Rice University, Houston, TX 77005

Topical A: Systems Biology