Preliminary Program subject to change
TA006 In Silico Systems Biology I
OverviewA critical component of systems biology is the development of in silico approaches to understand systems of interest. For this session, papers discussing novel uses of in silico methods to understand biological systems, as well as the development of new technologies and algorithms for in silico systems analysis are welcome. Research including experimental work is particularly encouraged.
Primary SponsorTopical A: Systems Biology (TA)

Chair

Ranjan Srivastava
Assistant Professor
University of Connecticut
191 Auditorium Rd., Unit 3222
Storrs, CT 06269
Phone Number: (860) 486-2802
Fax Number: (860) 486-2959
Email: srivasta@engr.uconn.edu

CoChair

Jeffrey D. Varner
Assistant Professor
Chemical and Biomolecular Engineering
Cornell University
Olin Hall
Ithaca, NY 14853
Phone Number: (607) 255 8656
Fax Number: (607) 255 9166
Email: jdv27@cornell.edu

CoChair

Anand R. Asthagiri
Chemical Engineering
California Institute of Technology
1200 E. California Blvd MC 210-41
Pasadena, CA 91125
Phone Number: 626-395-8130
Email: anand@cheme.caltech.edu
In Silico Design of Synthetic Tetracycline-Inducible Regulatory Gene Networks
Vassilios Sotiropoulos, Chemical Engineering and Material Science, University of Minnesota, 151 Amundson Hall, 421 Washington Ave SE, Minneapolis, MN 55455 and Yiannis N. Kaznessis, Chemical Engineering. and Materials. Science, University of Minnesota, 499, Walter Library, 117, Pleasant St. SE, Minneapolis, MN 55455
Cellular Biosynthesis Responds to Changing Nutrient Environments: Predicting in Vivo Behavior from in Vitro Models
Patrick F. Suthers, Department of Chemical Engineering, The Pennsylvania State University, 147 Fenske Lab, University Park, PA 16802, Richard Gourse, University of Wisconsin-Madison, 420 Henry Mall, Madison, WI 53706 and John Yin, Chemical and Biological Engineering, University of Wisconsin-Madison, 3633 Engineering Hall, 1415 Engineering Drive, Madison, WI 53706
Design and Mathematical Modeling of a Quorum Sensing Based Synthetic Ecosystem with Applications to Competitive Mixed Cultures
Pavan Kumar Reddy Kambam, Michael A. Henson and Lianhong Sun, Department of Chemical Engineering, University of Massachusetts Amherst, 686 N. Pleasant Street, Amherst, MA 01003
Theoretical Considerations and Computational Analysis of Polyketide Biosynthesis Pathways
Joanna González-Lergier, Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Road, E136, Evanston, IL 60208, Linda J. Broadbelt, Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Road E136, Evanston, IL 60208 and Vassily Hatzimanikatis, Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Rd., Evanston, IL 60208
Break
Identification of a Mechanistic Model of Calcium Crosstalk and Caspase Activation in Mammalian Apoptosis
Jeffrey D. Varner and Anjali Dhiman, Chemical and Biomolecular Engineering, Cornell University, Olin Hall, Ithaca, NY 14853
Clinical Mutations in the Epidermal Growth Factor Receptor and Relevance to Oncogenic Transformations: from Molecular to Systems Level Modeling
Andrew Shih1, Yingting Liu1, Jeremy Purvis2, Sung-Hee Chou3, Mark A. Lemmon3 and Ravi Radhakrishnan4, (1)Bioengineering, University of Pennsylvania, 120 Hayden Hall, 3320 Smithwalk, Philadelphia, PA 19104, (2)Genomics and Computational Biology, University of Pennsylvania, 120 Hayden Hall, 3320 Smithwalk, Philadelphia, PA 19104, (3)Biochemistry and Biophysics, University of Pennsylvania, 120 Hayden Hall, 3320 Smithwalk, Philadelphia, PA 19104, (4)Department of Bioengineering, University of Pennsylvania, 120 Hayden Hall, 3320 Smithwalk, Philadelphia, PA 19104
Sensitivity Analysis of Mammalian Circadian Clocks
Henry P. Mirsky, Program in Biomolecular Science and Engineering, University of California - Santa Barbara, Santa Barbara, CA 93101-9611, Rudiyanto Gunawan, Department of Chemical and Biomolecular Engineering, National University of Singapore, 119077, Singapore, Stephanie R. Taylor, Department of Computer Science, University of California - Santa Barbara, Santa Barbara, CA 93101-9611 and Francis J. Doyle III, Department of Chemical Engineering, University of California - Santa Barbara, Santa Barbara, CA 93101-9611

Topical A: Systems Biology