Binder Selection in Pharmaceutical Granulation: Wetting, Spreading, Stickiness and Strength
Stefaan J. R. Simons, Department of Chemical Engineering, University College London, Torrington Place, London, WC1E 7JE, United Kingdom, Rob Ward, ERP Phase 2a Site Champion, Devlab, Merck Sharp & Dohme, Hertford Road, Hoddesdon, Herts, EN11 9BU, United Kingdom, Shaun Fitzpatrick, Development Laboratories, Merck Sharp & Dohme, Hertford Road, Hertfordshire EN11 9BU, Hoddesdon, United Kingdom and Cristina Jimenez, Chemical Engineering, University College London, Torrington Place, London, WC1E 7JE, United Kingdom |
Granulation of Hydrophobic Powders Via Solid Spreading Nucleation
Karen P. Hapgood, Chemical Engineering, Monash University, Clayton, VIC, 3800, Australia |
The Microscopic Study of Granulation Mechanisms and Their Effect on the Non-Uniformity of Granule Properties
Phung K. Le1, Paul Avontuur2, Michael J. Hounslow1 and Agba D. Salman1, (1)Chemical and Process Engineering, The University of Sheffield, Mappin St, S1, 3JD, Sheffield, United Kingdom, (2)Pharmaceutical Development, GlaxoSmithKline Research &Development Limited, New Frontiers Science Park, Third Avenue, Harlow, Essex, New Frontier, United Kingdom |
Top-Spray Fluidised Bed Coating: Scale-up Using Response Surface Methodology
Peter Dybdahl Hede1, Poul Bach1 and Anker D. Jensen2, (1)Solid Products Development, Novozymes A/S, Smørmosevej 11, DK-2880, Denmark, (2)Department of Chemical Engineering, Technical University of Denmark, Building 229, DK-2800 Lyngby, Denmark |
Study of the Mechanisms during Drying of a Pharmaceutical Fluid Bed Granulation: Correlation of Residual Water Content with the Chemical Stability of the Formulation
Padma J. Narayan, Robert Batten, Bridget Larson, Meegan LeMott, Hong Ren Wang, Stephanie Tokarczyk, Ruby Burke, Marco Verwijs, Di Chen and Chris Galli, TransForm Pharmaceuticals, Inc., 29 Hartwell Ave, Lexington, MA 02421 |
Effect of Initial Particle Size and Initial Distribution Shape (Unimodal and Bimodal) on the Growth Kinetics and Mechanism of Wet Granulation in a Laboratory-Scale High Shear Mixer by Means of Image Processing and Analysis
Alvaro Realpe and Carlos Velázquez, Chemical Engineering, University of Puerto Rico, Miradero, Road 108, Km 3.0, Mayaguez, PR 00680 |
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