Preliminary Program subject to change
TA008 Synthetic Systems Biology II
OverviewSystems biology is the study of whole biological ensembles, rather than isolated parts, in order to build a predictive biological understanding of a defined system’s behavior. Synthetic biology has been defined as the design and construction of systems that exhibit complex dynamical or logical behavior. The intersection between these two fields is likely to significantly enhance efforts in design-based biological engineering and therefore greatly increase human capability. This session will cover current applications of systems biology theory and techniques to aid in the design of synthetic biological systems. In addition, efforts that apply synthetic biology research as new tools to expand systems-level understanding or as new concepts in systems biology are of interest.
Primary SponsorTopical A: Systems Biology (TA)

Chair

Jason Haugh
Associate Professor
Chemical & Biomolecular Engineering
North Carolina State University
Raleigh, NC 27695
Phone Number: 919-513-3851
Fax Number: 919-515-3465
Email: jason_haugh@ncsu.edu

CoChair

Christina Smolke
Chemical Engineering
California Institute of Technology
Pasadena, CA 91125
Phone Number: 626-395-2460
Email: smolke@cheme.caltech.edu
Optimizing Biological Circuits: Integrating Rational Design with Directed Evolution
Eric L. Haseltine, Department of Chemical Engineering, California Institute of Technology, Division of Chemistry & Chemical Engineering 210-41, Pasadena, CA 91125 and Frances H. Arnold, Chemistry & Chemical Engineering, California Institute of Technology, Pasadena, CA 91125
HIV's Evolution of Resistance to Antiviral Gene Therapy Is Predictable and Utilizes Novel Cooperative Mechanisms
Joshua N. Leonard, Department of Chemical Engineering, University of California Berkeley, 201 Gilman Hall, Berkeley, CA 94720 and David V. Schaffer, Department of Chemical Engineering and Helen Wills Neuroscience Institute, University of California Berkeley, 201 Gilman Hall, Berkeley, CA 94720
Engineering Ligand-Regulated Rnai Substrates as Novel Tools for Probing and Programming Cellular Systems
Chase L. Beisel and Christina Smolke, Chemical Engineering, California Institute of Technology, Pasadena, CA 91125
Tunable Promoters for the Synthesis and Analysis of Functional Gene Networks
Curt R. Fischer1, Hal S. Alper1, Elke Nevoigt1 and Gregory N. Stephanopoulos2, (1)Chemical Engineering, MIT, 77 Massachusetts Ave, 56-422, Cambridge, MA 02139, (2)Department of Chemical Engineering, MIT, 77 Massachusetts Ave, 56-422, Cambridge, MA 02139
Computational Design of Synthetic Biological Circuits
Madhukar S. Dasika, Department of Chemical Engineering, Penn State University, 147A Fenske Lab, University Park, PA 16802 and Costas D. Maranas, Department of Chemical Engineering, The Pennsylvania State University, 112, Fenske Lab, Univeristy Park, PA 16802
Computer Aided Design of Modular Protein Devices: Logical "and" Gene Activation
Howard Salis, Department of Chemical Engineering and Materials Science, University of Minnesota, 151 Amundson Hall, 421 Washington Ave SE, Minneapolis, MN 55455 and Yiannis N. Kaznessis, Chemical Engineering. and Materials. Science, University of Minnesota, 499, Walter Library, 117, Pleasant St. SE, Minneapolis, MN 55455
In Vitro Integration of Multiple Metabolic Systems for the Production of Membrane Proteins
Jessica J. Wuu, Chemical Engineering, Stanford University, MC 5025, Stanford, CA 94305 and James R. Swartz, Stanford University, Department of Chemical Engineering, Stanford, CA 94305-5025

Topical A: Systems Biology