Modeling the ErbB Signaling Network in MCF-7 Breast Cancer Cells and Analysis of Ligand-Dependent Responses
Marc R. Birtwistle1, Mariko Hatakeyama2, Noriko Yumoto2, Jan B. Hoek3, Boris N. Kholodenko3 and Babatunde A. Ogunnaike1, (1)Chemical Engineering, University of Delaware, 150 Academy St., Newark, DE 19716, (2)Genomic Services Center, RIKEN, Yokohama City, Japan, (3)Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, 1020 Locust St., Philadelphia, PA 19107 |
Simulation of Non-Specific Protein-Mrna Interactions in the Eif4f Translation Initiation Factor Complex
James Magee, School of Chemical Engineering and Analytical Science, University of Manchester, PO Box 88, Sackville Street, Manchester M60 1QD, United Kingdom and Jim Warwicker, Faculty of Life Sciences, University of Manchester, PO Box 88, Sackville Street, Manchester M60 1QD, United Kingdom |
A General Model for Ultrasensitivity Arising from Single Protein Multisite Modifications
Xiaoxia (Nina) Lin1, Yuan Gao1, Yaoyun Shi2 and George M. Church1, (1)Harvard Molecular Technology Group & Lipper Center for Computational Genetics, Harvard Medical School, 77 Ave. Louis Pasteur, NRB-238, Boston, MA 02115, (2)Electrical Engineering and Computer Science, University of Michigan, 1301 Beal Avenue, Ann Arbor, MI 48109 |
Spatial Organization of Egf Receptors and Its Implications for Signaling
Kapil Mayawala, Department of Chemical Engineering, University of Delaware, 150 Academy Street, Newark, DE 19716, Dionisios G. Vlachos, University of Delaware, Department of Chemical Engineering, 150 Academy St., 325 Colubrn Lab, Newark, DE 19716 and Jeremy S. Edwards, Chemical and Nuclear Engineering, University of New Mexico |
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How T Cells Hunt for Antigen in Lymphoid Tissue
Bo Jin1, Alan S. Perelson2 and Arup K. Chakraborty1, (1)Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, (2)Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545 |
From Ligand Binding to Transcription Activation: Insilico Simulation of Tumor Necrosis Factor-Induced Nuclear Factor Kappa B Activation Using Ibrena Software Package
Gang Liu, SUNY at Buffalo, 303 Furnas Hall, Buffalo, NY 14260 and Sriram Neelamegham, Chemical and Biological Engineering, SUNY at Buffalo, 303 Furnas Hall, Buffalo, NY 14260 |
Antigen Quality Regulates Signaling and Degradation in the Immunological Synapse
Jayajit Das1, Saso Cemerski2, Jason W. Locasale3, Phoebe Arnold2, Daved Fremont2, Paul Allen2, Andrey S. Shaw4 and Arup K. Chakraborty5, (1)Chemical Engineering, Massachusetts Institute of Technology, E19-238, 70 Massachusetts Avenue, Cambridge, MA 02139, (2)Department of Pathology, Washington University School of University, St Louis, MO 63110, (3)Biological Engineering, Massachusetts Institute of Techonology, 50 Ames St, E19-534, Cambridge, MA 02139, (4)Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid Ave, Box 8118, St Louis, MO 63110, (5)Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 |
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