Type 1 diabetes, previously known as juvenile diabetes, is caused when activated T-cells, mainly CD8+, destroy the insulin producing beta-cell population in the pancreas. The reason for this over active T-cell response is unknown and current research has only been able to provide limited information based on mouse models and humans who have died shortly after developing the disease.

Using the information provided by previous biological studies it is possible to create a mathematical model which details the response of T-cells, beta-cells, and insulin levels based on glucose appearance and amount of time spent in the body. The intermediate and long term glucose dynamics are taken into account and help us determine how much the beta-cell mass can change before diabetes onset. The results are produced graphically to show the dynamics of each variable as well as the strength of interaction between CD8+ T-cell and the deregulation of glucose. This model can then be used in future studies to predict how a diabetic would respond to certain biological stimuli.

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