Preliminary Program subject to change
TI021 Advances in Api Process Development
OverviewThe application of PATs in process development laboratories has expedited development timelines, while providing increased process understanding. Traditional engineering approaches like kinetic regression and mass transfer analysis using PAT data and subsequent process simulation will be the focus of this session. Authors are encouraged to submit papers discussing novel techniques aimed at solving process problems and interesting API case studies.
Primary SponsorTopical I: Pharmaceutical Engineering for the 21^st Century (TI)
Co-Sponsor(s)Pharmaceuticals (15b)

Chair

Shailendra Bordewekar
Abbott Labs
1401 Sheridan Rd.
North Chicago, IL 60064
Phone Number: 847 935-8660
Email: shailendra.bordawekar@abbott.com

CoChair

Scott Jones
Bristol-Myers Squibb
1 Squibb Drive,
New Brunswick, NJ 08903
Phone Number: 732 227-5186
Email: scott.jones@bms.com
Dynamic Impact Of Water Thermodynamics On Normal Phase Chromatography
David Willcox, Process Development, Abbott Laboratories, 1401 Sheridan Road, Dept R452-R13-2, North Chicago, IL 60091
Application Of In-Line Transmission Nir For Improved Process Understanding And Control Of A Continuous Mixing Process
Gregory M. Troup1, John P. Higgins1, Craig A. Mckelvey2, Michael Lowinger2, Jeff S. Ko3, Luke R. Schenck3, Robert F. Meyer3 and Brit L. Rudeen3, (1)Process Analytics, Merck & Co. Inc., 770 Sumneytown Pike, West Point, PA 19486, (2)Materials Characterization & Technology Assessment, Merck & Co. Inc., 770 Sumneytown Pike, West Point, PA 19486, (3)Pharmaceutical Commercialization Technology, Merck & Co. Inc., 770 Sumneytown Pike, West Point, PA 19486
Solid State Form Conversion Process
Christopher L. Burcham, Chemical Product Research and Development; Process Definition, Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, IN 46285 and Jeffrey T. Vicenzi, Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, IN 46285
Development And Implementation Of A Drying Process For An Amorphous Api Solid
Yao-En (David) Li1, Alex Coles2, Gerrie Liaw1 and Stephen Tyler1, (1)Global Pharmaceutical Operations, Manufacturing Science and Technology, Dept 045B, Building R13-2,, Abbott Laboratories, 1401 Sheridan Road, North Chicago, IL 60064, (2)Abbott Laboratories, Queenborough, Kent ME11 5EL, United Kingdom
Break
New Spectrophotometric Method for the Determination of Ambroxol Hydrochloride Using Artificial Neural Networks
Asha Immanuel Raju Chaduvula, Chemical Engineering, Andhra University, Andhra University, Visakhapatnam - 530 003, AP, INDIA, Visakhapatnam, 530003, India and Kiran Babu Uppuluri, Nagarjuna University, Bapatla Engineering College, Bapatla, India
The Use Of Pat In The Laboratory To Define And Optimize Api Manufacturing Processes
Mark A. LaPack, Chemical Process R&D, Eli Lilly and Company, Lilly Research Labs South, Indianapolis, IN 46285
Batch Process End Point Using Pca And Dpca Model Based On Ftir And Calorimetry Data Measurements
Shan Lin1, Shekhar Viswanath2, James Marek3, Steve Richter1, Zhi Wang1 and Clifford Mitchell4, (1)GPRD Engineering, Abbott Laboratories, 1401 Sheridan Rd, North Chicago, IL 60064-6292, (2)Process R&D, Abbott Laboratories, Dept R452, Bldg R8-3, 1401 Sheridan Rd., North Chicago, IL 60064, (3)GPRD Process Engineering, Abbott Laboratories, 1401 Sheridan Rd., MS R13-2, North Chicago, IL 60064-6292, (4)GPRD process analytical, Abbott Laboratories, 1401 Sheridan Rd, North Chicago, IL 60064-6292

Topical I: Pharmaceutical Engineering for the 21Century