Preliminary Program subject to change
TI014 Particle Engineering in the Active Pharmaceutical Ingredient and Drug Product Manufacturing
OverviewPhysical properties of pharmaceutical particles are greatly affected by particle size distribution and morphology. In many occasions the particles need to be engineered to meet certain formulation and process requirements. This session highlights advances in particle engineering to address process and formulation issues in the pharmaceutical industry. Particle engineering techniques in both API synthesis and drug product formulation are welcome. Sample cases include production of small crystals to improve bioavailability or compactability, particle size enlargement or morphology modification to improve powder flowability and bulk density, and granulation to improve drug product formulation processes, etc.
Primary SponsorTopical I: Pharmaceutical Engineering for the 21^st Century (TI)
Co-Sponsor(s)Pharmaceuticals (15b)

Chair

Bing-Shiou Yang
Principal Scientist
Boehringer Ingelheim Pharmaceuticals, Inc.
900 Ridgebury Rd./P.O. Box 368
Ridgefield, CT 06877-0368
Phone Number: 203-791-6883
Email: byang2@rdg.boehringer-ingelheim.com

CoChair

Praveen K. Sharma
Research Investigator II
Process Research & Development
Bristol-Myers Squibb Co.
1 Squibb Drive
New Brunswick, NJ 08903
Phone Number: 732-227-5186
Email: praveen.sharma@bms.com
Seeding--Friend or Foe?
San Kiang, Chiajen Lai, Thomas LaPorte, Fernando Quiroz, Lori Spangler, Jean Tom and Zhongmin Xu, Bristol Myers Squibb, New Brunswick, NJ 08903
A High Intensity Emulsification Method For The Production Of Nanoparticles
Eric Jayjock, Chemical and Biochemical Engineering, Rutgers University, PIscataway, NJ 08817, M. Silvina Tomasone, Rutgers University, PIscataway, NJ 08817 and Fernando J. Muzzio, Rutgers University, Chemical and Biochemical Engineering, 98 Brett Road, Piscataway, NJ 08854
Precipitation of Micro/nanoparticles by Enhanced Energy Dissipating Impinging Jets in Stirred-Tank Reactors
Giuseppe Di Benedetto1, Ewa Sukcik1, Piero M. Armenante1 and Somenath Mitra2, (1)Otto H. York Department of Chemical Engineering, New Jersey Institute of Technology, 323 King Blvd., Newark, NJ 07102-1982, (2)Department of Chemistry and Environmental Science, New Jersey Institute of Technology, 323 King Blvd., Newark, NJ 07102-1982
Development of a Particle Size Analysis Method for Dry and Wet Granulation
Jennifer Wang, Niranjan Kottala, Robert Jerzewski and Emil Friedman, Bristol-Myers Squibb, One Squibb Drive, New Brunswick, NJ 08903
Break
Computational Modelling Of The Anderson Cascade Impactor
Eric Jayjock, Chemical and Biochemical Engineering, Rutgers University, PIscataway, NJ 08817, Justin P. Lacombe, Rutgers University, 98 Brett Road, Piscataway, NJ 08854 and Fernando J. Muzzio, Rutgers University, Chemical and Biochemical Engineering, 98 Brett Road, Piscataway, NJ 08854
Controlled Nanoparticle Agglomeration As A Low-Density Dry Powder Aerosol Formulation Strategy
Lianjun Shi1, Laura J. Peek2, Carl Plumley3, Mark Bailey3 and Cory Berkland2, (1)Department of Chemical and Petroleum Engineering, University of Kansas, 2030 Becker Drive, Lawrence, KS 66047, (2)University of Kansas, 2030 Becker Drive, Lawrence, KS 66047, (3)Chemical and Petroleum Engineering, University of Kansas, 2030 Becker Drive, Lawrence, KS 66047

Topical I: Pharmaceutical Engineering for the 21Century