| Preliminary Program subject to change |
| 15C00 Advances in Cell Culture |
| As the number and quantity of recombinant proteins in development and commercial production has increased over the last few years, the demand on process development and manufacturing facilities has increased as well. While some of this demand can be met by building new infrastructures and facilities, a more efficient and less costly means of meeting these needs is by designing higher productivity processes that are well characterized and robust. This session will focus on recent developments in the field of cell culture process development and engineering with emphasis on enhancing yield and improving robustness of the culture process (i.e., excluding cell line manipulations). Topics include, but are not limited to, advances in bioprocess optimization, bioreactor design and operation, control schemes, scale up/scale down methods, and process analytical techniques for cell culture. |
| Bioengineering (15c) |
| Pharmaceuticals (15b) |
Chair
Sarah W. Harcum
Associate Professor
Department of Bioengineering
Clemson University
501 Rhodes Hall
Clemson, SC 29634
Phone Number: 864-656-6865
Email: harcum@clemson.edu
CoChair
M. Nazmul Karim
Chemical Engineering
Texas Tech University
Lubbock, TX 79409-3121
Phone Number: 806-742-3553
Email: naz.karim@ttu.edu
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Arrayed Bioreactor System For Screening And Optimizing Process Parameters For Recombinant Protein Production In Mammalian Cell Culture
Muhammad A.S. Chaudhry, Mario Jardon, Do Yun Kim and James M. Piret, Michael Smith Laboratories, University of British Columbia, 2185 East Mall, Vancouver, BC V6T 1Z4, Canada |
A Self-Feeding Roller Bottle For Continuous Cell Culture
R. Eric Berson, Chemical Engineering, University of Louisville, Ernst 106, University of Louisville, Louisville, KY 40292 and Goetz Friederichs, NxStage Medical, Inc., Lawrence, MA 01843 |
Impact Of Impeller Design On Antibody Production By Chinese Hamster Ovary Cells
Sandeepa Sandadi, Patricia Rose, John Bowers and Dennis Rendeiro, Biological & Sterile Product Development, Schering-Plough Research Institute, 1011 Morris Avenue, Union, NJ 07083 |
Modeling Of Individualistic Mammalian Cell Behavior Towards Environmental And Physiological Changes Using Population Balances
Srinivas Karra and M. Nazmul Karim, Chemical Engineering Department, Texas Tech University, Lubbock, TX 79409-3121 |
High Throughput Cell Culture Process Optimization By Using Green Fluorescence Protein (Gfp) To Simultaneously Monitor Cell Growth And Protein Production In Microbioreactor Array And Perfusion Bioreactor
Xudong Zhang, Chemical and Biomolecular Engineering, Ohio State University, 125 Koffolt Laboratories, 140 West 19th Ave., Columbus, OH 43210 and Shang-Tian Yang, Chemical and Biomolecular Engineering, The Ohio State University, Room 125A, 140 W. 19th Ave., Columbus, OH 43210 |
Characterization Of The C8161 Melanoma Cell Line For Use In A Tissue Based Bioreactor System
Gregory Rutkowski, Chemical Engineering, University of Minnesota, Duluth, 176 Engineering Bldg, 1303 Ordean Court, Duluth, MN 55804 |
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