Preliminary Program subject to change
15C08 Thermodynamics of Protein Folding and Aggregation
OverviewThis session seeks submissions focused on experimental and theoretical characterization and prediction of the thermodynamics and mechanism(s) of protein folding, and the role of aggregation as an on- or off-pathway aspect of (un)folding. Aggregation in this context is intended to include both reversible association and net irreversible aggregate formation. Preference will be given to presentations that provide insights of general utility, and those focused on relatively complex (un)folding pathways such as multi-domain and natively multimeric proteins.
Primary SponsorBioengineering (15c)
Co-Sponsor(s)Thermodynamics and Transport Properties (01a)

Chair

Christopher J. Roberts
Assistant Professor
Department of Chemical Engineering
University of Delaware
Newark, DE 19716
Phone Number: 302-831-0838
Fax Number: 302-831-1048
Email: roberts@che.udel.edu

CoChair

Thomas M. Truskett
Chemical Engineering and Institute for Theoretical Chemistry
The University of Texas at Austin
1 University Station
C0400
Austin, TX 78712
Phone Number: 123-456-7890
Email: truskett@che.utexas.edu
Ultra-Fast Folding Of The Villin Subdomain: Nanosecond T-Jump Measurements In Denaturant
Troy Cellmer1, William Eaton2 and Jim Hofrichter2, (1)Laboratory of Chemical Physics, NIH/NIDDK, 9000 Rockville Pike, Building 5, Room 106, Bethesda, MD 20892, (2)Laboratory of Chemical Physics, NIH/NIDDK, 9000 Rockville Pike, Bethesda, MD 20892
In Silico Protein Fragmentation Reveals The Importance Of Critical Nuclei In Domain Reassembly
Lydia M. Contreras, Cornell University, Chemical and Biomolecular Engineering, Ithaca, NY 14853, Ernesto Borrero-Quintana, Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14853, Fernando A. Escobedo, Department of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14853 and Matthew P. DeLisa, Cornell University, Ithaca, NY 14850
Quaternary Self-Association of Gst-Tagged Viral Proteins
D. I. Lipin1, Yap Pang Chuan2, L. Lua3 and A. P. J. Middelberg3, (1)Centre for Biomolecular Engineering, Department of Chemical Engineering, The University of Queensland, Brisbane, Australia, (2)Centre for Biomolecular Engineering, Australian Institute of Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Australia, (3)Centre for Biomolecular Engineering, Australian Institue of Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Australia
Memory and Reversibility of Insulin Oligomers
Mirco Sorci1, Arpan Nayak1, Chuang-Chung Lee2, Gregory J. McRae2, Robert Grassucci3, Ingrid Hahn3, Joachim Frank3 and Georges Belfort1, (1)Rensselaer Polytechnic Institute, 110 8th st, Troy, NY 12180-3590, (2)MIT, Cambridge, MA 02141, (3)Wadsworth Center and Howard Hughes Medical Institute
Intermission
Subtle Defects In Transthyretin Quaternary Structure Prevent Its Inhibitory Action On Beta-Amyloid Aggregation
Regina M. Murphy, Lin Liu and Jie Hou, Chemical and Biological Engineering, University of Wisconsin, 1415 Engineering Drive, Madison, WI 53706
Computer Simulation Of Protein Aggregation Kinetics Using An Intermediate Resolution Model
Erin M. Phelps, Department of Chemical and Biomolecular Engineering, North Carolina State University, College of Engineering 1, Box 7905, 911 Partners Way, Raleigh, NC 27695 and Carol K. Hall, Department of Chemical and Biomolecular Engineering, North Carolina State University, Engineering Building I, Box 7905, 911 Partners Way, Raleigh, NC 27695
Towards Understanding Non-Integer Order Kinetics of Protein Denaturation
Jan Sefcik, Peter Grancic and Carl J. Schaschke, Chemical and Process Engineering, University of Strathclyde, James Weir Building, 75 Montrose Street, Glasgow, United Kingdom

Food, Pharmaceutical & Bioengineering Division