Preliminary Program subject to change
T3007 Advances in Ce and Microdevice Technology for Genomic Analysis
OverviewMicrofluidic-based DNA and protein separation systems are beginning to emerge from the research laboratory and appear as commercially available products for use in a variety of genomic analysis applications. If sufficient miniaturization can be achieved, these microfabricated systems will enjoy a tremendous cost advantage over today’s conventional macroscale systems, thereby ensuring a central role in future genomic analysis efforts such as the ambitious goal of sequencing a genome for $1,000 or less. Strategies to develop improved sieving media based on a variety of polymeric and non-polymeric materials incorporating uniform and reproducible microstructures promise to generate tremendous improvements in the achievable level of separation performance. In addition, separation matrices composed of nanofabricated structures constructed directly on the surfaces of silicon, glass, and plastic substrates offer exciting possibilities in terms of exerting precise control over pore size and sieving properties. Novel techniques to analyze DNA and proteins by directly probing the motion of single molecules either through nanoscale fluidic channels or through membrane channel nanopores also show enormous potential. Chemical engineers continue to make important contributions in these areas, and we invite abstracts related to any aspect of the development or study of biomolecule separation technology at the microscale, or on miniaturized devices.
Primary SponsorTopical 3: 2007 Annual Meeting of the American Electrophoreses Society (AES) (T3)

Chair

Michael T. Bowser
Assistant Professor
Chemistry
University of Minnesota
207 Pleasant St. SE
Minneapolis, MN 55455
Phone Number: 612-624-0873
Fax Number: 612-626-7541
Email: bowser@chem.umn.edu

CoChair

Kevin D. Dorfman
Assistant Professor
Department of Chemical Engineering and Materials Science
University of Minnesota
151 Amundson Hall
421 Washington Ave. SE
Minneapolis, MN 55455
Phone Number: 612-624-5560
Fax Number: 612-626-7246
Email: dorfman@cems.umn.edu
Electrophoresis Of DNA Molecules Confined In Virtual Nanochannels
Gary W. Slater and Martin Bertrand, Physics, University of Ottawa, 150 Louis-Pasteur, Ottawa, ON K1N 6N5, Canada
Molecular Dyamics Simulations Of Dynamic Coatings For Quenching Electroosmotic Flow
Owen A. Hickey and Gary W. Slater, Physics, University of Ottawa, 150 Louis Pasteur, Ottawa, ON K1N6N5, Canada
The Nanoporous Morphology Of Hydrogel Separation Matrices For DNA Electrophoresis
Jian Wang1, Hugo Y. Acosta2 and Victor M. Ugaz1, (1)Artie McFerrin Department of Chemical Engineering, Texas A&M University, 3122 TAMU, College Station, TX 77843, (2)Department of Chemical Engineering, Universidad Industrial de Santander, Bucaramanga, Colombia
Engineered Entangled Polymer Networks And System Design For Improved Four-Color Sequencing Of DNA By Microchip Electrophoresis
Daniel G. Hert, Christopher P. Fredlake and Annelise E. Barron, Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208
Microfabricated Microemulsion Droplet Generator Enables The Pcr Colony Front End Of The Microbead Integrated DNA Sequencer
Palani Kumaresan1, Chaoyong James Yang2 and Richard A. Mathies2, (1)Department of Mechanical Engineering, University of California, Berkeley, Berkeley, CA 94720, (2)Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720
Microfluidic Selection Of Aptamers
Michael T. Bowser1, Bryan R. Fonslow2, Renee K. Mosing2 and Ryan Turgeon2, (1)Chemistry, University of Minnesota, 207 Pleasant St. SE, Minneapolis, MN 55455, (2)University of Minnesota, 207 Pleasant St. SE, Minneapolis, MN 55455

Topical 3: 2007 Annual Meeting of the American Electrophoresis Society (AES)